Rosemeyer D, Brackmann P, de Boer H, Freitag J, Koblitz D K, Müller K
Z Gastroenterol. 1986 Oct;24(10):635-44.
1115 examinations with the Pancreolauryl-Test (PLT) were carried out and assessed on 918 non-selected patients with various gastro-enterologic diseases. Depending on the severity of the exocrine insufficiency, sensitivity varied in confirmed chronic pancreatitis (n = 54). Overall sensitivity was 69%, in chronic pancreatitis with steatorrhoe 100%, and 54% in moderate insufficiency. In all patients not suffering from pancreatic diseases (n = 789) specificity was 77%. Since the PLT was frequently pathological in patients with subtotal gastrectomy (gastric resection) and active peptic lesion, specificity was also determined excluding these cases (29% of all patients without pancreatic disease). This resulted in a specificity of 86%. Gastric hyperacidity should be taken into consideration as a possible source of errors (for example, in the condition following an ulcer). Age, weight and alcohol consumption as well as diseases of the bile duct and liver, had no influence on specificity. Urine collection errors, occurring in 10% of the patients investigated, could be avoided by determination of fluorescein in the serum. Our results from a series of examinations on non-selected patients with a 6% prevalence of chronic pancreatitis indicated that PLT is likely to increase predictive value in selected application. If the oesophagus-gastro-duodenoscopy is non-pathological but the PLT gives a pathological result, further pancreatic investigative procedures should be carried out.
对918例未经过挑选的患有各种胃肠疾病的患者进行了1115次月桂基胰酶试验（PLT）检查并进行评估。根据外分泌功能不全的严重程度，在确诊的慢性胰腺炎患者（n = 54）中敏感性有所不同。总体敏感性为69%，在伴有脂肪泻的慢性胰腺炎中为100%，在中度功能不全中为54%。在所有未患胰腺疾病的患者（n = 789）中，特异性为77%。由于在胃大部切除术（胃切除术）和活动性消化性病变患者中PLT经常呈病理性，因此在排除这些病例（所有无胰腺疾病患者的29%）后也测定了特异性。这使得特异性达到了86%。胃胃酸分泌过多应被视为可能的误差来源（例如，在溃疡后的情况）。年龄、体重、饮酒量以及胆管和肝脏疾病对特异性没有影响。在所调查的患者中有10%出现尿液收集错误，通过测定血清中的荧光素可以避免这种情况。我们对慢性胰腺炎患病率为6%的未经过挑选的患者进行的一系列检查结果表明，PLT在特定应用中可能会提高预测价值。如果食管-胃-十二指肠镜检查无病理性，但PLT给出病理性结果，则应进一步进行胰腺检查程序。
