Department of Obstetrics and Gynecology, Xijing Hospital, Air Forth Military Medical University, 127 Changle West Road, Xincheng District, Xi'an City, Shaanxi Province, China.
Mol Cell Biochem. 2024 Oct;479(10):2545-2563. doi: 10.1007/s11010-023-04861-6. Epub 2023 Oct 26.
Cancer stem cells (CSCs) are a class of cells with self-renewal and multi-directional differentiation potential, which are present in most tumors, particularly in aggressive tumors, and perform a pivotal role in recurrence and metastasis and are expected to be one of the important targets for tumor therapy. Studies of tumor metabolism in recent years have found that the metabolic characteristics of CSCs are distinct from those of differentiated tumor cells, which are unique to CSCs and contribute to the maintenance of the stemness characteristics of CSCs. Moreover, these altered metabolic profiles can drive the transformation between CSCs and non-CSCs, implying that these metabolic alterations are important markers for CSCs to play their biological roles. The identification of metabolic changes in CSCs and their metabolic plasticity mechanisms may provide some new opportunities for tumor therapy. In this paper, we review the metabolism-related mechanisms of CSCs in order to provide a theoretical basis for their potential application in tumor therapy.
癌症干细胞（CSCs）是一类具有自我更新和多向分化潜能的细胞，存在于大多数肿瘤中，尤其是在侵袭性肿瘤中，在肿瘤的复发和转移中起着关键作用，有望成为肿瘤治疗的重要靶点之一。近年来对肿瘤代谢的研究发现，CSCs 的代谢特征与分化的肿瘤细胞不同，这些特征是 CSCs 所特有的，有助于维持 CSCs 的干性特征。此外，这些改变的代谢特征可以驱动 CSCs 和非 CSCs 之间的转化，这表明这些代谢改变是 CSCs 发挥其生物学作用的重要标志物。鉴定 CSCs 的代谢变化及其代谢可塑性机制可能为肿瘤治疗提供一些新的机会。本文综述了 CSCs 的代谢相关机制，以期为其在肿瘤治疗中的潜在应用提供理论依据。
