Department of Medicine.(DIMED), Unit of Metabolic Disease, University of Padova University of Padova, Via Giustiniani 2, 35128, Padova, Italy.
Endocrine. 2024 Oct;86(1):48-57. doi: 10.1007/s12020-024-03886-1. Epub 2024 Jun 3.
Diabesity is a condition where an individual has both diabetes and obesity, which can lead to severe complications including cardiovascular disease, a leading cause of mortality. Recently, cancer has become a leading cause of excess hospitalizations, and both diabetes and obesity are associated with a higher risk of developing several types of cancer. In this review, we propose that chronic stress significantly increases this association. Managing diabetes and obesity is challenging as they both cause significant distress. The relationship between stress and cancer is interconnected, with anxiety and depression being common in cancer patients. Cancer diagnosis and treatment can cause lasting changes in the body's neuroendocrine system, with stress causing an excessive release of catecholamines and prostaglandins in patients undergoing cancer surgery, which promotes the spread of cancer to other parts of the body. Furthermore, stress could significantly increase the risk of cancer in patients with diabetes, obesity, or both.
糖尿病肥胖症是一种个体同时患有糖尿病和肥胖症的情况，可导致严重的并发症，包括心血管疾病，这是主要的死亡原因。最近，癌症已成为导致住院人数过多的主要原因，而糖尿病和肥胖症都与更高的多种癌症发病风险相关。在这篇综述中，我们提出慢性压力显著增加了这种关联。管理糖尿病和肥胖症具有挑战性，因为它们都会造成严重的困扰。压力与癌症之间的关系是相互关联的，癌症患者中常见焦虑和抑郁。癌症诊断和治疗会导致身体神经内分泌系统的持久变化，癌症手术患者的应激会导致儿茶酚胺和前列腺素的过度释放，从而促进癌症向身体其他部位扩散。此外，压力可能会显著增加糖尿病、肥胖症或两者兼有患者的癌症风险。
