Huikuri H V, Airaksinen J K, Lilja M, Takkunen J T
Acta Diabetol Lat. 1986 Jul-Sep;23(3):193-200. doi: 10.1007/BF02624705.
In order to evaluate the left ventricular (LV) response to isometric exercise in diabetics, 15 young insulin-dependent diabetic subjects and 12 control subjects of similar age and sex distribution performed a handgrip test during echocardiography. No base-line differences in hemodynamic or echocardiographic parameters were found between diabetic and control subjects. The heart rate and blood pressure responses to handgrip exercise were similar in the two groups, and LV dimensions, shortening fraction and velocity of circumferential fiber shortening remained unchanged in both groups. Three diabetic subjects had an impaired LV functional response to handgrip (a decrease of more than 5 percentage units in the shortening fraction). These 3 patients had high HbA1 values (17.6-18.2%) and modest correlations existed between decrease in the shortening fraction during handgrip and concentrations of HbA1 (r = 0.70, p less than 0.01) and fasting blood glucose (r = 0.62, p less than 0.01). Thus, most young insulin-dependent diabetic subjects appear to have a normal LV response to isometric exercise, but poor blood glucose control seems to be accompanied by a slight impairment of LV functional reserve.
为了评估糖尿病患者左心室（LV）对等长运动的反应，15名年轻的胰岛素依赖型糖尿病患者和12名年龄及性别分布相似的对照者在超声心动图检查期间进行了握力测试。糖尿病患者和对照者之间在血流动力学或超声心动图参数方面未发现基线差异。两组对握力运动的心率和血压反应相似，两组的左心室尺寸、缩短分数和圆周纤维缩短速度均保持不变。3名糖尿病患者的左心室对握力的功能反应受损（缩短分数下降超过5个百分点）。这3例患者的糖化血红蛋白（HbA1）值较高（17.6 - 18.2%），握力期间缩短分数的下降与HbA1浓度（r = 0.70，p < 0.01）和空腹血糖（r = 0.62，p < 0.01）之间存在适度相关性。因此，大多数年轻的胰岛素依赖型糖尿病患者似乎左心室对等长运动的反应正常，但血糖控制不佳似乎伴随着左心室功能储备的轻微受损。
