Larsson H, Frederiksen J, Stigsby B, Olesen J
Acta Neurol Scand. 1986 Sep;74(3):195-202. doi: 10.1111/j.1600-0404.1986.tb07855.x.
The value of flight of colours (FOC), i.e. the succession of coloured afterimages following light stimulation, in diagnosing and following visual impairment was evaluated in 65 patients with multiple sclerosis (MS). Previous optimistic reports of the use of a pocket flashlight (PFL) method could not be confirmed, and are ascribed to inadequate methods. An electronic flashlight (EFL) method developed by us, proved a significantly better diagnostic tool (61% abnormal versus 18% abnormal). The EFL method was diagnostically less sensitive than pattern reversal visual evoked potential (PR-VEP) (80% abnormal). It did, however, add to PR-VEP by diagnosing 16 eyes with normal PR-VEP latency. The EFL method reflected the degree of degenerative changes in the central visual pathways and may be of value in following the disease activity in MS. The potential of the EFL method may be further improved by proposed modifications.
对65例多发性硬化症（MS）患者评估了颜色视觉残留（FOC）的价值，即光刺激后彩色后像的相继出现情况，以用于诊断和跟踪视力损害。先前关于使用袖珍手电筒（PFL）方法的乐观报告无法得到证实，原因是方法不够完善。我们开发的电子手电筒（EFL）方法被证明是一种明显更好的诊断工具（异常率为61%，而PFL方法为18%）。EFL方法在诊断上不如图形翻转视觉诱发电位（PR-VEP）敏感（异常率为80%）。然而，它确实能补充PR-VEP的不足，因为它能诊断出16只PR-VEP潜伏期正常的眼睛。EFL方法反映了中枢视觉通路的退行性变化程度，可能对跟踪MS疾病活动有价值。通过提出的改进措施，EFL方法的潜力可能会进一步提高。
