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利伐沙班的一种罕见副作用:药物性肝损伤。

An Uncommon Side Effect of Rivaroxaban: A Drug-Induced Liver Injury.

作者信息

Karki Bhesh R, Jasaraj Ranjit B, Jha Suman K, Maisuradze Nodari, Yu Qi

机构信息

Internal Medicine, State University of New York (SUNY) Downstate Health Sciences University, New York City, USA.

Internal Medicine, Mount Sinai Hospital Medical Center of Chicago, Chicago, USA.

出版信息

Cureus. 2023 Sep 25;15(9):e45949. doi: 10.7759/cureus.45949. eCollection 2023 Sep.

DOI:10.7759/cureus.45949
PMID:37885502
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10599792/
Abstract

Rivaroxaban is rarely associated with drug-induced liver injury (DILI). A 57-year-old male was sent to the emergency room from an endocrine clinic for a presyncope evaluation. His exam was non-focal, and his laboratory work was remarkable for the hepatocellular pattern of liver injury. Upon detailed assessment, he was found to have DILI due to rivaroxaban. The liver function tests improved after its discontinuation. This case emphasizes the need for early recognition and timely intervention to prevent further hepatotoxicity from the culprit drug.

摘要

利伐沙班很少与药物性肝损伤(DILI)相关。一名57岁男性从内分泌诊所被送往急诊室进行晕厥前期评估。他的检查无局灶性异常,实验室检查结果显示肝细胞型肝损伤显著。经过详细评估,发现他的药物性肝损伤是由利伐沙班引起的。停用利伐沙班后肝功能检查结果有所改善。该病例强调了早期识别和及时干预以防止罪魁祸首药物进一步导致肝毒性的必要性。

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本文引用的文献

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2
Drug-induced liver injury: Pathogenesis, epidemiology, clinical features, and practical management.药物性肝损伤:发病机制、流行病学、临床特征及实用管理。
Eur J Intern Med. 2022 Mar;97:26-31. doi: 10.1016/j.ejim.2021.10.035. Epub 2021 Nov 9.
3
Rivaroxaban Is Associated With Higher Rates of Gastrointestinal Bleeding Than Other Direct Oral Anticoagulants : A Nationwide Propensity Score-Weighted Study.
利伐沙班与其他直接口服抗凝剂相比,胃肠道出血发生率更高:一项全国范围内的倾向评分加权研究。
Ann Intern Med. 2021 Nov;174(11):1493-1502. doi: 10.7326/M21-1474. Epub 2021 Oct 12.
4
Acute liver failure after changing oral anticoagulant from apixaban to rivaroxaban.口服抗凝剂从阿哌沙班更换为利伐沙班后出现急性肝衰竭。
BMJ Case Rep. 2021 Apr 28;14(4):e240719. doi: 10.1136/bcr-2020-240719.
5
Acute Liver Failure Secondary to Drug-Induced Liver Injury.药物性肝损伤致急性肝衰竭。
Clin Liver Dis. 2020 Feb;24(1):75-87. doi: 10.1016/j.cld.2019.09.005. Epub 2019 Oct 31.
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Epidemiology, Predisposing Factors, and Outcomes of Drug-Induced Liver Injury.药物性肝损伤的流行病学、易患因素和结局。
Clin Liver Dis. 2020 Feb;24(1):1-10. doi: 10.1016/j.cld.2019.08.002. Epub 2019 Oct 28.
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