用于核磁共振信号放大的水兼容且可回收的多相SABRE催化剂。
Water-Compatible and Recyclable Heterogeneous SABRE Catalyst for NMR Signal Amplification.
作者信息
Min Sein, Baek Juhee, Kim Jisu, Jeong Hye Jin, Chung Jean, Jeong Keunhong
机构信息
Department of Chemistry, Seoul Women's University, Seoul 01797, South Korea.
Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523, United States.
出版信息
JACS Au. 2023 Oct 10;3(10):2912-2917. doi: 10.1021/jacsau.3c00487. eCollection 2023 Oct 23.
A water-compatible and recyclable catalyst for nuclear magnetic resonance (NMR) hyperpolarization via signal amplification by reversible exchange (SABRE) was developed. The [Ir(COD)(IMes)Cl] catalyst was attached to a polymeric resin of bis(2-pyridyl)amine (heterogeneous SABRE catalyst, HET-SABRE catalyst), and it amplified the H NMR signal of pyridine up to (-) 4455-fold (43.2%) at 1.4 T in methanol and (-) 50-fold (0.5%) in water. These are the highest amplification factors ever reported among HET-SABRE catalysts and for the first time in aqueous media. Moreover, the HET-SABRE catalyst demonstrated recyclability by retaining its activity in water after more than three uses. This newly designed polymeric resin-based heterogeneous catalyst shows great promise for NMR signal amplification for biomedical NMR and MRI applications in the future.
开发了一种通过可逆交换信号放大（SABRE）实现核磁共振（NMR）超极化的水兼容且可回收的催化剂。[Ir(COD)(IMes)Cl]催化剂附着于双（2 - 吡啶基）胺的聚合物树脂上（非均相SABRE催化剂，HET - SABRE催化剂），在1.4 T磁场下，它在甲醇中使吡啶的1H NMR信号放大至（-）4455倍（43.2%），在水中放大至（-）50倍（0.5%）。这些是HET - SABRE催化剂中迄今报道的最高放大倍数，且首次在水性介质中实现。此外，HET - SABRE催化剂在经过三次以上使用后仍能在水中保持活性，展现出可回收性。这种新设计的基于聚合物树脂的非均相催化剂在未来生物医学NMR和MRI应用的NMR信号放大方面显示出巨大潜力。
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