Laboratory of Magnetic Resonance Microimaging, International Tomography Center, SB RAS, 3A Institutskaya St., Novosibirsk, 630090, Russia.
Novosibirsk State University, 2 Pirogova St., Novosibirsk, 630090, Russia.
Angew Chem Int Ed Engl. 2017 Aug 21;56(35):10433-10437. doi: 10.1002/anie.201705014. Epub 2017 Jul 28.
The hyperpolarization of heteronuclei via signal amplification by reversible exchange (SABRE) was investigated under conditions of heterogeneous catalysis and microtesla magnetic fields. Immobilization of [IrCl(COD)(IMes)], [IMes=1,3-bis(2,4,6-trimethylphenyl), imidazole-2-ylidene; COD=cyclooctadiene] catalyst onto silica particles modified with amine linkers engenders an effective heterogeneous SABRE (HET-SABRE) catalyst that was used to demonstrate a circa 100-fold enhancement of N NMR signals in N-pyridine at 9.4 T following parahydrogen bubbling within a magnetic shield. No N NMR enhancement was observed from the supernatant liquid following catalyst separation, which along with XPS characterization supports the fact that the effects result from SABRE under heterogeneous catalytic conditions. The technique can be developed further for producing catalyst-free agents via SABRE with hyperpolarized heteronuclear spins, and thus is promising for biomedical NMR and MRI applications.
通过可逆交换信号放大（SABRE）实现杂核的超极化，在多相催化和微特斯拉磁场条件下进行了研究。将[IrCl(COD)(IMes)]，[IMes=1,3-双（2,4,6-三甲基苯基），咪唑-2-亚基; COD=环辛二烯]催化剂固定在带有胺接头修饰的硅胶颗粒上，产生了一种有效的多相 SABRE（HET-SABRE）催化剂，该催化剂用于在磁场屏蔽内进行-parahydrogen 鼓泡后，在 9.4 T 下证明 N-吡啶中的 N-NMR 信号增强了约 100 倍。催化剂分离后，从上清液中未观察到 N-NMR 增强，这与 XPS 表征一起支持了以下事实：这些效应是在多相催化条件下通过 SABRE 产生的。该技术可以进一步发展，用于通过 SABRE 产生具有超极化杂核自旋的无催化剂试剂，因此有望用于生物医学 NMR 和 MRI 应用。
