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基于 SQUID 的超极化材料超低场 MRI 技术，采用可交换信号放大。

SQUID-based ultralow-field MRI of a hyperpolarized material using signal amplification by reversible exchange.

机构信息

Ultra-low Magnetic Field Team, Korea Research Institute of Standards and Science (KRISS), 267, Gajeong-ro, Yuseong-gu, Daejeon, 34113, Republic of Korea.

Department of Chemistry, Korea Military Academy, 574, Hwarang-ro, Nowon-gu, Seoul, 01805, Republic of Korea.

出版信息

Sci Rep. 2019 Aug 27;9(1):12422. doi: 10.1038/s41598-019-48827-5.

DOI:10.1038/s41598-019-48827-5
PMID:31455823
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6712030/
Abstract

The signal amplification by reversible exchange (SABRE) technique is a very promising method for increasing magnetic resonance (MR) signals. SABRE can play a particularly large role in studies with a low or ultralow magnetic field because they suffer from a low signal-to-noise ratio. In this work, we conducted real-time superconducting quantum interference device (SQUID)-based nuclear magnetic resonance (NMR)/magnetic resonance imaging (MRI) studies in a microtesla-range magnetic field using the SABRE technique after designing a bubble-separated phantom. A maximum enhancement of 2658 for H was obtained for pyridine in the SABRE-NMR experiment. A clear SABRE-enhanced MR image of the bubble-separated phantom, in which the para-hydrogen gas was bubbling at only the margin, was successfully obtained at 34.3 μT. The results show that SABRE can be successfully incorporated into an ultralow-field MRI system, which enables new SQUID-based MRI applications. SABRE can shorten the MRI operation time by more than 6 orders of magnitude and establish a firm basis for future low-field MRI applications.

摘要

信号放大可逆交换（SABRE）技术是一种非常有前途的方法，可以增加磁共振（MR）信号。SABRE 在低场或超低场的研究中可以发挥特别大的作用，因为它们的信噪比低。在这项工作中，我们在微特斯拉磁场范围内设计了一个气泡分离的仿体后，使用 SABRE 技术进行了实时超导量子干涉器件（SQUID）基于的核磁共振（NMR）/磁共振成像（MRI）研究。在 SABRE-NMR 实验中，吡啶的 H 获得了最大 2658 的增强。在 34.3 μT 时，成功地获得了仅在边缘冒泡的气泡分离仿体的清晰 SABRE 增强 MR 图像。结果表明，SABRE 可以成功地纳入超低场 MRI 系统，从而实现新的基于 SQUID 的 MRI 应用。SABRE 可以将 MRI 操作时间缩短 6 个数量级以上，为未来的低场 MRI 应用奠定坚实的基础。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26d5/6712030/4947f1b15b68/41598_2019_48827_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26d5/6712030/30a01afa2954/41598_2019_48827_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26d5/6712030/747d80557968/41598_2019_48827_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26d5/6712030/d3b887e735a9/41598_2019_48827_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26d5/6712030/a6250155974e/41598_2019_48827_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26d5/6712030/4947f1b15b68/41598_2019_48827_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26d5/6712030/30a01afa2954/41598_2019_48827_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26d5/6712030/747d80557968/41598_2019_48827_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26d5/6712030/d3b887e735a9/41598_2019_48827_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26d5/6712030/a6250155974e/41598_2019_48827_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26d5/6712030/4947f1b15b68/41598_2019_48827_Fig5_HTML.jpg

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Chemistry. 2019 Jul 2;25(37):8829-8836. doi: 10.1002/chem.201901192. Epub 2019 May 30.
2
In-situ Overhauser-enhanced nuclear magnetic resonance at less than 1 μT using an atomic magnetometer.使用原子磁力计在小于1微特斯拉的磁场下进行原位奥弗豪泽增强核磁共振。
J Magn Reson. 2019 Mar;300:149-152. doi: 10.1016/j.jmr.2019.02.001. Epub 2019 Feb 10.
3
Quantification of hyperpolarisation efficiency in SABRE and SABRE-Relay enhanced NMR spectroscopy.
JACS Au. 2023 Oct 10;3(10):2912-2917. doi: 10.1021/jacsau.3c00487. eCollection 2023 Oct 23.
4
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6
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7
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RSC Adv. 2022 Apr 26;12(20):12477-12506. doi: 10.1039/d2ra01346k. eCollection 2022 Apr 22.
8
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9
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10
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