Lin Alexis, Dent Gelonia L, Davies Suzy, Dominguez Zarena M, Cioffredi Leigh-Anne, McLemore Gabrielle L, Maxwell Jessie R
Gustavus Adolphus College, Saint Peter, MN, United States.
Department of Mathematics, Medgar Evers College, CUNY, Brooklyn, NY, United States.
Front Pediatr. 2023 Oct 11;11:1278227. doi: 10.3389/fped.2023.1278227. eCollection 2023.
Cannabinoid use in all populations is increasing as legalization across the United States continues. Concerningly, there is a lack of caution provided by medical providers to pregnant individuals as to the impact the use of cannabinoids could have on the developing fetus. Research continues in both the preclinical and clinical areas, and is severely needed, as the potency of delta-9-tetrahydrocannabinol (THC), the primary psychoactive component of cannabis, has increased dramatically since the initial studies were completed. Thus far, clinical studies raise compelling evidence for short term memory deficits, impulse control issues, and attention deficiencies following prenatal cannabinoid exposure (PCE). These changes may be mediated through epigenetic modifications that not only impact the current offspring but could carry forward to future generations. While additional studies are needed, a pregnancy pause from cannabinoid products should be strongly recommended by providers to ensure the optimal health and well-being of our future generations.
随着大麻在美国各地的合法化，所有人群中大麻素的使用量都在增加。令人担忧的是，医疗服务提供者并未向孕妇提供足够的警示，告知其使用大麻素可能对发育中的胎儿产生的影响。临床前和临床领域的研究仍在继续，而且迫切需要进行这些研究，因为自最初的研究完成以来，大麻的主要精神活性成分Δ9-四氢大麻酚（THC）的效力已大幅提高。到目前为止，临床研究为产前大麻素暴露（PCE）后出现的短期记忆缺陷、冲动控制问题和注意力缺陷提供了令人信服的证据。这些变化可能是通过表观遗传修饰介导的，表观遗传修饰不仅会影响当前的后代，还可能延续到未来几代人。虽然还需要更多的研究，但医疗服务提供者应强烈建议孕妇暂停使用大麻素产品，以确保我们后代的最佳健康和福祉。
