Langley P G, Hughes R D, Ton H Y, Silk D B, Williams R
Int J Artif Organs. 1979 Jul;2(4):207-10.
In previous studies severe side effects, including irreversible hypotension, platelet losses and rises in Swank screen filtration pressure, have been recorded during the treatment by charcoal haemoperfusion of patients with fulminant hepatic failure. It has also been demonstrated that rises in Swank screen filtration pressure in an in vitro test circuit are due to the presence of platelet aggregates. In this study Prostacyclin was infused at a constant rate, to give a blood concentration of 5 ng/ml, into the in vitro circuit just prior to the charcoal column. Rises in Swank screen filtration pressure were prevented, and it was also shown that the giving of a bolus dose of Prostacyclin (400 ng/ml blood concentration) reversed rises in Swank screen filtration pressure that have already occurred. On the basis of these findings, Prostacyclin would be expected to be of considerable clinical value in the prevention of adverse platelet reactions to charcoal haemoperfusion when carried out in patients with fulminant hepatic failure.
在先前的研究中，已记录到暴发性肝衰竭患者在接受活性炭血液灌流治疗期间出现严重副作用，包括不可逆性低血压、血小板减少以及斯旺克筛滤压升高。研究还表明，体外测试回路中斯旺克筛滤压升高是由于血小板聚集体的存在。在本研究中，在活性炭柱之前以恒定速率向体外回路输注前列环素，使血液浓度达到5纳克/毫升。斯旺克筛滤压升高得到了预防，并且还表明给予大剂量前列环素（血液浓度400纳克/毫升）可逆转已经出现的斯旺克筛滤压升高。基于这些发现，预计前列环素在预防暴发性肝衰竭患者进行活性炭血液灌流时出现的不良血小板反应方面具有相当大的临床价值。
