Weston M J, Woods H F, Bunting S, Moncada S, Vane J R
Proc Eur Dial Transplant Assoc. 1979;16:225-31.
During charcoal haemoperfusion (CHP) in dogs, use of prostacyclin (PGI2) in addition to heparin reduced the loss of platelets (25 +/- 6 vs 83 +/- 2%), the formation of platelet aggregates as judged by screen filtration pressure (65 +/- 6 vs 249 +/- 25mm Hg) and fibrinogen consumption (20 +/- 5 vs 46 +/- 6%). Prostacyclin also delayed neutralisation of heparin during CHP. This improvement of biocompatibility may now allow a proper assessment of CHP in liver failure.
在犬类的木炭血液灌注（CHP）过程中，除肝素外使用前列环素（PGI2）可减少血小板损失（25±6%对83±2%），通过筛滤压判断的血小板聚集体形成（65±6mmHg对249±25mmHg）以及纤维蛋白原消耗（20±5%对46±6%）。前列环素还可延迟CHP过程中肝素的中和。这种生物相容性的改善现在可能允许对肝衰竭中的CHP进行恰当评估。
