Eberhard G, Hellbom E
Acta Psychiatr Scand. 1986 Sep;74(3):255-62. doi: 10.1111/j.1600-0447.1986.tb06242.x.
Thirty-two schizophrenic patients, previously treated with antipsychotics, were treated with haloperidol decanoate and flupenthixol decanoate in a double-blind cross-over study. The drugs were given for 24 weeks each at an individually adapted dose. The last three injections of either drug were given at fixed 4-week intervals. The mean dose over the two treatment periods changed from 131 mg (start) to 151 mg (week 24) in the haloperidol decanoate group and from 56 mg to 66 mg in the flupenthixol decanoate group, the inter-drug ratio being 2.3:1. During the first study period, the patients' condition remained rather stable with both drugs. After crossing-over, the symptoms were further reduced with haloperidol decanoate but increased with flupenthixol decanoate. Side effects of the two drugs were comparable and were generally few and mild. It was concluded that 4-week intramuscular administration of haloperidol decanoate provides appropriate control of schizophrenic symptoms, but that flupenthixol decanoate should be dosed at shorter intervals.
在一项双盲交叉研究中，对32名先前接受过抗精神病药物治疗的精神分裂症患者使用癸酸氟哌啶醇和癸酸氟奋乃静进行治疗。两种药物均以个体适配剂量给药24周。两种药物的最后三次注射均以固定的4周间隔进行。癸酸氟哌啶醇组在两个治疗期的平均剂量从131毫克（开始）变为151毫克（第24周），癸酸氟奋乃静组从56毫克变为66毫克，两种药物的剂量比为2.3:1。在第一个研究期内，两种药物治疗时患者病情均保持相当稳定。交叉用药后，癸酸氟哌啶醇使症状进一步减轻，而癸酸氟奋乃静使症状加重。两种药物的副作用相当，总体较少且轻微。得出的结论是，每4周肌肉注射一次癸酸氟哌啶醇可适当控制精神分裂症症状，但癸酸氟奋乃静的给药间隔应更短。
