Sakagami K, Miyazaki M, Matsuoka J, Shiozaki S, Saito S, Orita K
Acta Med Okayama. 1986 Oct;40(5):249-55. doi: 10.18926/AMO/31928.
An artificial liver support system for plasma exchange and plasma perfusion through BR-601 resin using a membrane separator was applied to 5 patients with postoperative liver failure. Percent absorption of total and direct bilirubin, and of bile acids were 77.1 +/- 6.4, 78.4 +/- 6.1, and 93.4 +/- 3.6%, respectively, when 250 ml of plasma was treated. Percent reductions in total and direct bilirubin, and in bile acids were 24.5 +/- 5.8, 25.5 +/- 5.8 and 30.9 +/- 8.5%, respectively. In contrast, percent reductions in total and direct bilirubin, and in bile acids by plasma exchange were 30.9 +/- 13.3, 34.5 +/- 12.5 and 24.2 +/- 8.5%, respectively. The coma grade was improved in 4 out of 5 cases, but unfortunately the patients did not recover. In conclusion, plasma perfusion through BR-601 resin is expected to play a promising role in artificial liver support systems because of its capacity to absorb bilirubin and bile acids.
一种使用膜分离器通过BR - 601树脂进行血浆置换和血浆灌注的人工肝支持系统应用于5例术后肝衰竭患者。当处理250毫升血浆时，总胆红素、直接胆红素和胆汁酸的吸收百分比分别为77.1±6.4%、78.4±6.1%和93.4±3.6%。总胆红素、直接胆红素和胆汁酸的降低百分比分别为24.5±5.8%、25.5±5.8%和30.9±8.5%。相比之下，通过血浆置换的总胆红素、直接胆红素和胆汁酸的降低百分比分别为30.9±13.3%、34.5±12.5%和24.2±8.5%。5例中有4例昏迷等级得到改善，但遗憾的是患者未能康复。总之，由于BR - 601树脂具有吸收胆红素和胆汁酸的能力，预计其在人工肝支持系统中可发挥重要作用。
