Alarabi A A, Wikström B, Lööf L, Danielson B G
Dept. of Internal Medicine, University Hospital, Uppsala, Sweden.
Scand J Gastroenterol. 1992;27(3):223-6. doi: 10.3109/00365529208999953.
The efficacy of plasma perfusion through a new anionic resin, BR-350, for palliation of intractable pruritus secondary to intrahepatic cholestasis was studied in four patients. The treatment was given in a daily 2-h session on 3 consecutive days and was followed by repeated treatment periods each 3rd to 4th week. The patients experienced symptomatic improvement during the first treatment period, and the treatment was well tolerated. Adsorption of bile acids across the filter was efficient and resulted in a bile acid concentration gradient pre- to post-resin of 92%. Thus plasma perfusion through the ion resin BR-350 is an effective and safe treatment for symptomatic relief of intractable pruritus in cholestatic liver disease and may reduce hospitalization time and increase the quality of life.
在四名患者中研究了通过新型阴离子树脂BR - 350进行血浆灌注对缓解肝内胆汁淤积继发的顽固性瘙痒的疗效。治疗每天进行一次，每次2小时，连续3天，随后每3至4周重复治疗期。患者在第一个治疗期出现症状改善，且治疗耐受性良好。胆汁酸在滤器上的吸附有效，导致树脂前后胆汁酸浓度梯度为92%。因此，通过离子树脂BR - 350进行血浆灌注是一种有效且安全的治疗方法，可缓解胆汁淤积性肝病中的顽固性瘙痒症状，并可能缩短住院时间，提高生活质量。
