Theriault C, Fitzpatrick P J
Am J Clin Oncol. 1986 Dec;9(6):510-6. doi: 10.1097/00000421-198612000-00009.
A retrospective study of 271 patients with parotid carcinoma seen between 1958 and 1980 is reported. Among these were 64 (24%) mucoepidermoid tumors (all degrees of differentiation), 50 (18%) adenocarcinomas, 40 (15%) malignant mixed tumors, 39 (14%) adenoid cystic carcinomas, 37 (14%) undifferentiated, 21 (8%) acinic, and 20 (7%) squamous cell carcinomas. The proportion of advanced (T3T4) to early (T1T2) tumors was 1.7:1. At diagnosis, 42 (15%) patients had regional metastases. An analysis for prognostic factors showed that the histology, tumor stage, regional metastases (No vs. N+), age, and damage to the facial nerve all influence cause-specific survival. After multivariate analysis the tumor size and the presence of regional metastases were the two most significant factors (p less than 0.0001 and 0.004). The prognostic characteristics were similar for the 67 (25%) patients treated by surgery and for the 169 (62%) patients treated with surgery and postoperative radiotherapy. Patients treated with combined therapy had a 10-year relapse-free rate of 62% compared to 22% for those treated by surgery alone (p = 0.0005).
报告了一项对1958年至1980年间收治的271例腮腺癌患者的回顾性研究。其中有64例（24%）黏液表皮样癌（所有分化程度）、50例（18%）腺癌、40例（15%）恶性混合瘤、39例（14%）腺样囊性癌、37例（14%）未分化癌、21例（8%）腺泡细胞癌和20例（7%）鳞状细胞癌。晚期（T3T4）与早期（T1T2）肿瘤的比例为1.7:1。诊断时，42例（15%）患者有区域转移。预后因素分析表明，组织学、肿瘤分期、区域转移（N0与N+）、年龄以及面神经损伤均影响特定病因生存率。多因素分析后，肿瘤大小和区域转移的存在是两个最显著的因素（p<0.0001和0.004）。接受手术治疗的67例（25%）患者和接受手术及术后放疗的169例（62%）患者的预后特征相似。联合治疗的患者10年无复发率为6
