Department of Molecular, Cellular and Biomedical Sciences, University of New Hampshire , Durham, New Hampshire, USA.
Pathogen and Microbiome Institute, Northern Arizona University , Flagstaff, Arizona, USA.
Microbiol Spectr. 2023 Dec 12;11(6):e0271523. doi: 10.1128/spectrum.02715-23. Epub 2023 Oct 27.
Inherent complexities in the composition of microbiomes can often preclude investigations of microbe-associated diseases. Instead of single organisms being associated with disease, community characteristics may be more relevant. Longitudinal microbiome studies of the same individual bats as pathogens arrive and infect a population are the ideal experiment but remain logistically challenging; therefore, investigations like our approach that are able to correlate invasive pathogens to alterations within a microbiome may be the next best alternative. The results of this study potentially suggest that microbiome-host interactions may determine the likelihood of infection. However, the contrasting relationship between Pd and the bacterial microbiomes of and indicate that we are just beginning to understand how the bat microbiome interacts with a fungal invader such as Pd.
微生物组的组成存在固有复杂性，这往往会妨碍对与微生物相关疾病的研究。与疾病相关的可能不是单个生物体，而是群落特征。对同一批蝙蝠进行纵向微生物组研究，观察病原体的出现和感染情况，这是理想的实验，但在实际操作中具有挑战性；因此，像我们这样能够将入侵病原体与微生物组内的变化相关联的研究方法可能是下一个最佳选择。本研究的结果可能表明，微生物组-宿主的相互作用可能决定感染的可能性。然而，Pd 与 和 的细菌微生物组之间的对比关系表明，我们才刚刚开始了解蝙蝠微生物组如何与 Pd 等真菌入侵者相互作用。
