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并且其代谢产物硫化氢会改变肠道微生物群落组成和自噬过程，促进结直肠癌的进展。

and its metabolite hydrogen sulfide alter gut microbiota composition and autophagy process and promote colorectal cancer progression.

机构信息

Department of Pharmaceutical Microbiology, School of Life Science and Technology, China Pharmaceutical University , Nanjing, China.

State Key Laboratory of Natural Medicines, China Pharmaceutical University , Nanjing, China.

出版信息

Microbiol Spectr. 2023 Dec 12;11(6):e0229223. doi: 10.1128/spectrum.02292-23. Epub 2023 Oct 27.

DOI:10.1128/spectrum.02292-23
PMID:37889013
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10714730/
Abstract

Colorectal cancer (CRC) is the second most common cancer in the world; the main treatment for CRC is immunosuppressive therapy, but this therapy is only effective for a small percentage of CRC patients, so there is an urgent need for a treatment with fewer side effects and higher efficacy. This study demonstrated that with increased abundance in CRC can regulate the autophagy process and disrupt normal intestinal microbiota by producing hydrogen sulfide, factors that may be involved in the development and progression of CRC. This study may provide a reference for future CRC treatment options that are efficient and have fewer side effects.

摘要

结直肠癌（CRC）是世界上第二常见的癌症；CRC 的主要治疗方法是免疫抑制疗法，但这种疗法仅对一小部分 CRC 患者有效，因此迫切需要一种副作用更少、疗效更高的治疗方法。本研究表明，在 CRC 中丰度增加可以通过产生硫化氢来调节自噬过程并破坏正常的肠道微生物群，这些因素可能参与 CRC 的发展和进展。本研究可能为未来高效低副作用的 CRC 治疗方案提供参考。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/993e/10714730/40220998e85d/spectrum.02292-23.f008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/993e/10714730/72fb247d8905/spectrum.02292-23.f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/993e/10714730/41c7bb0c5f01/spectrum.02292-23.f002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/993e/10714730/59b6d8a14380/spectrum.02292-23.f003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/993e/10714730/7082c7923bbe/spectrum.02292-23.f004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/993e/10714730/b4549811dcc9/spectrum.02292-23.f005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/993e/10714730/93db2561cbb3/spectrum.02292-23.f006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/993e/10714730/3de85b40c9a4/spectrum.02292-23.f007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/993e/10714730/40220998e85d/spectrum.02292-23.f008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/993e/10714730/72fb247d8905/spectrum.02292-23.f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/993e/10714730/41c7bb0c5f01/spectrum.02292-23.f002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/993e/10714730/59b6d8a14380/spectrum.02292-23.f003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/993e/10714730/7082c7923bbe/spectrum.02292-23.f004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/993e/10714730/b4549811dcc9/spectrum.02292-23.f005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/993e/10714730/93db2561cbb3/spectrum.02292-23.f006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/993e/10714730/3de85b40c9a4/spectrum.02292-23.f007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/993e/10714730/40220998e85d/spectrum.02292-23.f008.jpg

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引用本文的文献

[1]
Anaerobic gut bacteria and their potential role in the initiation, exacerbation, and development of human colorectal cancer: a narrative review.

Front Cell Infect Microbiol. 2025-7-25

[2]
Microbiota-driven epigenetic modifications in gastrointestinal cancer: Implications for pathogenesis and therapeutic strategies.

World J Microbiol Biotechnol. 2025-7-28

[3]
Diagnostic value of methane-hydrogen breath test combined with intestinal flora testing in screening for colorectal polyps.

Front Med (Lausanne). 2025-5-30

[4]
Deciphering microbial and metabolic influences in gastrointestinal diseases-unveiling their roles in gastric cancer, colorectal cancer, and inflammatory bowel disease.

J Transl Med. 2025-5-16

[5]
Gut microbiota - bidirectional modulator: role in inflammatory bowel disease and colorectal cancer.

Front Immunol. 2025-4-30

[6]
Innovative strategies targeting oral microbial dysbiosis: unraveling mechanisms and advancing therapies for periodontitis.

Front Cell Infect Microbiol. 2025-4-30

[7]
Gut microbiota-mitochondrial crosstalk in obesity: novel mechanistic insights and therapeutic strategies with traditional Chinese medicine.

Front Pharmacol. 2025-4-22

[8]
Helicobacter pylori, microbiota and gastric cancer - principles of microorganism-driven carcinogenesis.

Nat Rev Gastroenterol Hepatol. 2025-5

[9]
Interplay of m6A RNA methylation and gut microbiota in modulating gut injury.

Gut Microbes. 2025-12

[10]
Dysregulated genes in HIGK-treated and their possible association with HNSCC.

Mol Biol Res Commun. 2025

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