Dysregulated genes in HIGK-treated and their possible association with HNSCC.

The present study aims to identify the differentially expressed genes in HIGK treated with and their possible role in establishing head and neck squamous cell carcinoma. The study design follows a computational approach wherein multiple databases and tools are used to derive the possible association between exposure and the development of HNSCC. The GEOmnibus dataset GSE6927 provided data on the differentially expressed genes in the HIGK treated with . The GEO2R analysis revealed 22 differentially expressed genes in HIGK cells treated with . The expression profile of these genes was then analyzed in the HNSCC (TCGA, Firehose Legacy) dataset employing the UALCAN database. The present study revealed 5 genes , , , , and exhibiting similar expression patterns in -treated HIGK and HNSCC datasets. The and were found to be upregulated, and the genes , , and were downregulated. Among the five genes, the demonstrated a significant association with the survival of HNSCC patients. The low expression of presented a poor prognosis compared to the high expression. The study's results identified as a candidate gene involved in infection and HNSCC. Validating this result is necessary to gain insights into the role of the gene in developing HNSCC. Furthermore, probing the epigenetic factors targeting can be a potential therapeutic lead.