Williams Lauren E, Frishman William H
From the Department of Medicine, New York Medical College/Westchester Medical Center, Valhalla, NY.
Departments of Medicine and Cardiology, New York Medical College/Westchester Medical Center, Valhalla, NY.
Cardiol Rev. 2025;33(1):88-92. doi: 10.1097/CRD.0000000000000582. Epub 2023 Oct 27.
Botulinum neurotoxin (BoNT) is a toxin with a wide repertoire of well-known applications in cosmetics and medicine, such as treating migraine headaches, spasticity, and achalasia, and it has generally been shown to be safe and well-tolerated. In addition to its current successes in clinical practice, studies have also demonstrated the potential of BoNT to be used as a therapeutic agent for many cardiovascular conditions. Prior investigations, as well as trials currently underway, have showcased the safety and potential efficacy of BoNT in applications such as treating ischemia-reperfusion injury, hypertension, atrial fibrillation, and heart failure. While further study in humans, as well as improved statistical power in efficacy studies, are needed before its prospective use as a treatment for the aforementioned conditions, one might consider BoNT a potential cardiovascular agent.
肉毒杆菌神经毒素（BoNT）是一种毒素，在化妆品和医学领域有广泛的知名应用，如治疗偏头痛、痉挛和贲门失弛缓症，并且总体上已证明其安全性良好且耐受性佳。除了目前在临床实践中的成功应用外，研究还表明BoNT有潜力用作治疗多种心血管疾病的药物。先前的研究以及目前正在进行的试验，都展示了BoNT在治疗缺血再灌注损伤、高血压、心房颤动和心力衰竭等应用中的安全性和潜在疗效。虽然在将其前瞻性地用于治疗上述疾病之前，还需要在人体中进行进一步研究，并提高疗效研究的统计效力，但人们可能会认为BoNT是一种潜在的心血管药物。
