Tan Min, Zeng Jing, Zhang Fu-Zhong, Zhang Ye-Tao, Li Hongli, Fan Shu-Ting, Wang Jia-Xin, Yuan Minglong, Li Bang-Jing, Zhang Sheng
Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China.
University of Chinese Academy of Sciences, Beijing 100049, China.
ACS Appl Mater Interfaces. 2023 Oct 27. doi: 10.1021/acsami.3c10607.
Slow healing of wounds induces great pain in diabetic patients. However, developing new approaches to promote diabetic wound healing is still one of the toughest challenges in the medical field. Here, we constructed a new double-layer hydrogel to effectively regulate reactive oxygen species (ROS) on the wound and promote diabetic wound healing. The inner layer contains glucose oxidase (Gox), ferrocene-modified quaternary ammonium chitosan (Fc-QCs), and poly(β-cyclodextrin) (Pβ-CD), which is used to generate hydroxyl radicals (OH) for antibacterial in the early stage of wound healing and collapses gradually. The outer layer is composed of gelatin and dopamine. In the later stage of wound healing, the outer layer contacts the skin, which is beneficial for ROS clearance on the wound. Antibacterial, ROS scavenging, and wound healing experiments have shown that the double-layer hydrogel possesses two-stage ROS regulating properties for programmed diabetic wound healing. In conclusion, it will be one of the most potential dressings for treating diabetic wounds in the future.
伤口愈合缓慢会给糖尿病患者带来巨大痛苦。然而，开发促进糖尿病伤口愈合的新方法仍是医学领域最严峻的挑战之一。在此，我们构建了一种新型双层水凝胶，以有效调节伤口处的活性氧（ROS）并促进糖尿病伤口愈合。内层包含葡萄糖氧化酶（Gox）、二茂铁修饰的季铵化壳聚糖（Fc-QCs）和聚（β-环糊精）（Pβ-CD），其用于在伤口愈合早期产生羟基自由基（OH）进行抗菌，并逐渐降解。外层由明胶和多巴胺组成。在伤口愈合后期，外层与皮肤接触，有利于伤口处ROS的清除。抗菌、ROS清除和伤口愈合实验表明，这种双层水凝胶具有用于程序化糖尿病伤口愈合的两阶段ROS调节特性。总之，它将是未来治疗糖尿病伤口最具潜力的敷料之一。
