Seo Ja In, Lim Ji Hye, Jo Woo Min, Lee Jeong Keun, Song Seung Il
Department of Oral and Maxillofacial Surgery, Institute of Oral Health Science, Ajou University School of Medicine, 164 World cup-Ro, Yeongtong-Gu, Suwon-Si, Gyeonggi-Do, 16499, Republic of Korea.
Maxillofac Plast Reconstr Surg. 2023 Oct 27;45(1):40. doi: 10.1186/s40902-023-00405-6.
rhBMP-2 is regarded as the most potent osteoinductive growth factor, and it has been used in the oral cavity with different carriers. The purpose of this study is to evaluate the bone-regenerative effect of rhBMP-2 delivered with different carrier systems through three-dimensional cone beam computed tomography analysis.
A total of 112 patients underwent oral surgery with rhBMP-2 application (Group 1, n = 53) or without rhBMP-2 application (Group 2, n = 59). Group 1 was divided into 3 groups according to carriers, rhBMP-2 with allograft (Group 1-1, n = 34), rhBMP-2 with xenograft (Group 1-2, n = 5), and rhBMP-2 with absorbable collagen sponge (Group 1-3, n = 14). Cone beam computed tomography scans were taken before surgery (T0) 6 months after surgery (T1). The volume of defects was measured through the three-dimensional image analysis tool.
The average bone regeneration rate of Group 1 was significantly greater than that of Group 2. Within Group 1, the group that used allograft as a carrier (Group 1-1) showed significantly higher bone regeneration rates than the group that used absorbable collagen sponge as a carrier (Group 1-3).
The use of rhBMP-2 after oral surgery results in a superior bone regeneration rate compared to not using rhBMP-2, and its efficacy depends on the carriers it is used with. Allograft affects bone regeneration more than absorbable collagen sponge when it is carried with rhBMP-2. Therefore, the appropriate use of rhBMP-2 with suitable bone grafting materials is useful for promoting postoperative bone regeneration in oral surgery.
重组人骨形态发生蛋白-2（rhBMP-2）被认为是最有效的骨诱导生长因子，并且已与不同载体一起用于口腔。本研究的目的是通过三维锥形束计算机断层扫描分析评估rhBMP-2与不同载体系统联合应用时的骨再生效果。
共有112例患者接受口腔手术，其中应用rhBMP-2的患者为第1组（n = 53），未应用rhBMP-2的患者为第2组（n = 59）。第1组根据载体分为3组，即rhBMP-2与同种异体移植物联合应用（第1-1组，n = 34）、rhBMP-2与异种移植物联合应用（第1-2组，n = 5）、rhBMP-2与可吸收胶原海绵联合应用（第1-3组，n = 14）。在手术前（T0）和手术后6个月（T1）进行锥形束计算机断层扫描。通过三维图像分析工具测量缺损体积。
第1组的平均骨再生率显著高于第2组。在第1组中，使用同种异体移植物作为载体的组（第1-1组）的骨再生率显著高于使用可吸收胶原海绵作为载体的组（第1-3组）。
与未使用rhBMP-2相比，口腔手术后使用rhBMP-2可获得更高的骨再生率，其疗效取决于所使用的载体。当rhBMP-2与同种异体移植物联合应用时，其对骨再生的影响大于可吸收胶原海绵。因此，将rhBMP-2与合适的骨移植材料联合应用有助于促进口腔手术术后的骨再生。
