Bennett W M, Wood C A, Houghton D C, Gilbert D N
Am J Kidney Dis. 1986 Nov;8(5):292-6. doi: 10.1016/s0272-6386(86)80100-7.
Some of the factors that modify experimental aminoglycoside nephrotoxicity are reviewed. Maneuvers ready to be tested for effectiveness in the clinical use of these drugs are highlighted. The use of concomitant penicillins and changes in dosing strategy seem to be particularly exciting new leads toward elimination of clinical aminoglycoside nephrotoxicity.
本文综述了一些可改变实验性氨基糖苷类肾毒性的因素。重点介绍了那些有待在这些药物的临床应用中测试其有效性的策略。联合使用青霉素以及调整给药方案似乎是消除临床氨基糖苷类肾毒性方面特别令人振奋的新线索。
