犬类氨基糖苷类药物肾毒性：取决于药物、剂量和给药方案。
Aminoglycoside nephrotoxicity in dogs: dependence on drug, dose and regimen.
作者信息
Thompson W L, Powell S
出版信息
Scand J Infect Dis Suppl. 1980;Suppl 23:91-5.
PMID:6937972
Abstract
In female mongrel dogs nephrotoxicity of three aminoglycosides (gentamicin, tobramycin and netilmicin) was compared with relation to the cortical aminoglycoside concentration. A standard regimen of 45 mg/kg/day with constant intravenous infusion and once daily dosing of each aminoglycoside was used, and in subsequent dogs netilmicin daily dose was increased to an average of 73 mg/kg/day.
摘要
在雌性杂种犬中，比较了三种氨基糖苷类药物（庆大霉素、妥布霉素和奈替米星）的肾毒性与皮质氨基糖苷类药物浓度的关系。采用了每种氨基糖苷类药物持续静脉输注、每日一次给药、45mg/kg/天的标准方案，随后将奈替米星的每日剂量增加至平均73mg/kg/天。
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Aminoglycoside nephrotoxicity in dogs: dependence on drug, dose and regimen.犬类氨基糖苷类药物肾毒性：取决于药物、剂量和给药方案。
Scand J Infect Dis Suppl. 1980;Suppl 23:91-5.
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