Kochi Ryuzaburo, Osawa Shin-Ichiro, Jin Kazutaka, Ishida Makoto, Kanno Akitake, Iwasaki Masaki, Suzuki Kyoko, Kawashima Ryuta, Tominaga Teiji, Nakasato Nobukazu
Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.
Department of Epileptology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.
Clin Neurophysiol. 2023 Dec;156:69-75. doi: 10.1016/j.clinph.2023.09.010. Epub 2023 Oct 5.
To clarify whether preoperative language magnetoencephalography (MEG) predicts postoperative verbal memory (VM) changes in left mesial temporal lobe epilepsy (LMTLE).
We reviewed 18 right-handed patients with LMTLE who underwent anterior temporal lobectomy or selective amygdala hippocampectomy, 12 with (HS+) and 6 without hippocampal sclerosis (HS-). Patients underwent neuropsychological assessment before and after surgery. MEG was measured with an auditory verbal learning task in patients preoperatively and in 15 right-handed controls. Dynamic statistical parametric mapping (dSPM) was used for source imaging of task-related activity. Language laterality index (LI) was calculated by z-score of dSPM in language-related regions. LI in the region of HS+ and HS- was compared to controls. The correlation between LI and postoperative VM change was assessed in HS+ and HS-.
Preoperative LI in supramarginal gyrus showed greater right-shifted lateralization in both HS+ and HS- than in controls. Right-shifted LI in supramarginal gyrus was correlated with postoperative VM increase in HS+ (p = 0.019), but not in HS-.
Right-shifted language lateralization in dSPM of MEG signals may predict favorable VM outcome in HS+ of LMTLE.
Findings warrant further investigation of the relation between regional language laterality index and postoperative verbal memory changes.
明确术前语言磁脑图（MEG）是否能预测左侧颞叶内侧癫痫（LMTLE）患者术后言语记忆（VM）的变化。
我们回顾了18例接受前颞叶切除术或选择性杏仁核海马切除术的右利手LMTLE患者，其中12例有海马硬化（HS+），6例无海马硬化（HS-）。患者在手术前后接受神经心理学评估。术前对患者以及15名右利手对照者进行听觉言语学习任务的MEG测量。使用动态统计参数映射（dSPM）对任务相关活动进行源成像。通过语言相关区域dSPM的z分数计算语言优势指数（LI）。比较HS+和HS-区域的LI与对照者的LI。评估HS+和HS-中LI与术后VM变化之间的相关性。
术前，HS+和HS-患者的缘上回LI均显示出比对照者更明显的右侧化。缘上回右侧化的LI与HS+患者术后VM增加相关（p = 0.019），但与HS-患者无关。
MEG信号dSPM中的右侧化语言优势可能预测LMTLE的HS+患者有良好的VM结果。
研究结果值得进一步探讨区域语言优势指数与术后言语记忆变化之间的关系。
