Yarrington G, Figueroa J P, Massmann A, Kassis I, Nathanielsz P W
Am J Obstet Gynecol. 1986 Dec;155(6):1160-4. doi: 10.1016/0002-9378(86)90137-7.
Mesometrial and myometrial electromyograms have been recorded from ovariectomized nonpregnant ewes. After infusion with saline solution, the frequency of electromyographic events lasting less than 180 seconds in the myometrium was not different from the frequency of their occurrence in the mesometrium. During infusion of estradiol at 100 micrograms/24 hours, the frequency of events less than 180 seconds increased significantly in the myometrium but was unchanged in the mesometrium. Contracture activity (electromyographic events lasting more than 180 seconds) was significantly greater in the mesometrium than in the myometrium before estradiol administration. During estradiol infusion, contracture activity remained unchanged. These findings suggest that the mesometrial muscle may be a useful model to study the effects of various stimulators and inhibitors of uterine muscle function in the absence of stretch and local paracrine effects that occur in the uterus itself.
已从卵巢切除的未孕母羊记录了子宫系膜和子宫肌层的肌电图。注入盐溶液后，子宫肌层中持续时间少于180秒的肌电活动频率与子宫系膜中其出现频率无差异。在以100微克/24小时的剂量注入雌二醇期间，子宫肌层中持续时间少于180秒的活动频率显著增加，但子宫系膜中该频率未改变。在给予雌二醇之前，子宫系膜中的挛缩活动（持续时间超过180秒的肌电活动）显著高于子宫肌层。在注入雌二醇期间，挛缩活动保持不变。这些发现表明，子宫系膜肌可能是一个有用的模型，可用于在不存在子宫自身发生的牵张和局部旁分泌效应的情况下，研究各种子宫肌功能刺激剂和抑制剂的作用。
