Lotgering F K, Wallenburg H C
Am J Obstet Gynecol. 1986 Dec;155(6):1164-70. doi: 10.1016/0002-9378(86)90138-9.
In chronically instrumented pregnant ewes we studied the systemic, uterine, and fetal effects of increased uterine venous pressure with and without simultaneous changes in cardiac output, by occluding either the inferior vena cava or both uterine veins. Increased uterine venous pressure with no reduction in venous return of blood to the heart resulted in a reflex increase in arterial blood pressure. Infrarenal obstruction of the inferior vena cava resulted in a moderate reduction in venous return and cardiac output with no change in arterial blood pressure, while suprarenal obstruction of the inferior vena cava caused a major decrease in cardiac output as well as in arterial pressure. Uterine blood flow varied in proportion with perfusion pressure at all levels of obstruction. Uterine oxygen consumption and fetal oxygenation only decreased with suprarenal obstruction of the inferior vena cava, when uterine blood flow fell more than 50%.
在长期植入监测装置的妊娠母羊中，我们通过阻断下腔静脉或双侧子宫静脉，研究了在有或无心输出量同时变化的情况下，子宫静脉压升高对全身、子宫和胎儿的影响。子宫静脉压升高而回心血量未减少，导致动脉血压反射性升高。肾下水平阻断下腔静脉导致静脉回流量和心输出量适度减少，动脉血压无变化，而肾上水平阻断下腔静脉则导致心输出量以及动脉血压大幅下降。在所有梗阻水平，子宫血流量均与灌注压成比例变化。仅在肾上水平阻断下腔静脉且子宫血流量下降超过50%时，子宫氧耗量和胎儿氧合才会降低。
