Lang U, Prada J, Clark K E
Department of Obstetrics and Gynecology, University of Cincinnati College of Medicine, OH 45267-0526.
Eur J Obstet Gynecol Reprod Biol. 1993 Oct;51(2):131-8. doi: 10.1016/0028-2243(93)90025-8.
Released from aggregating platelets, serotonin (5HT) among other vasoactive components is considered to play an important role in preeclampsia, one of the most common medical complications of pregnancy. This study was designed to evaluate the simultaneous uterine and systemic vascular effects of systemically administered serotonin in pregnant sheep and compare them to the well known effects of angiotensin II and norepinephrine. Nine instrumented pregnant ewes received intravenous (inferior vena cava) infusions of increasing doses of serotonin, norepinephrine and angiotensin II in random order. Cardiac output, arterial blood pressure, heart rate, and uterine blood flow were recorded. Systemic administration of serotonin at doses of 2, 4, and 8 micrograms/kg body weight/min caused a slight increase in mean arterial blood pressure (1, 4 and 11%), a large decrease in uterine blood flow (10, 37, and 71%) but did not change cardiac output. Serotonin led to an increase in uterine vascular resistance with only small changes in systemic vascular resistance (UVR 17, 107, and 363% vs. SVR 3, 10 and 11%). In contrast, angiotensin II increased both systemic and uterine vascular resistance (SVR 16, 37, 56, and 95% and UVR 5, 16, 28 and 99%). Norepinephrine also raised both systemic and uterine vascular resistance, though to a different extent (SVR 5, 17, 37, and 118% vs. UVR 5, 46, 84 and 304%). Systemic infusions of serotonin in third trimester pregnant ewes resulted in uterine vasoconstriction. In contrast to the marked effect on the uterine vasculature, the systemic cardiovascular responses were small, thus demonstrating a nearly selective effect of serotonin on the uterine vasculature at the doses administered.(ABSTRACT TRUNCATED AT 250 WORDS)
血清素（5-羟色胺，5HT）与其他血管活性成分一起，从聚集的血小板中释放出来，被认为在子痫前期（妊娠最常见的医学并发症之一）中起重要作用。本研究旨在评估全身给予血清素对妊娠绵羊子宫和全身血管的同时作用，并将其与血管紧张素II和去甲肾上腺素的已知作用进行比较。9只植入仪器的妊娠母羊按随机顺序接受静脉（下腔静脉）输注递增剂量的血清素、去甲肾上腺素和血管紧张素II。记录心输出量、动脉血压、心率和子宫血流量。以2、4和8微克/千克体重/分钟的剂量全身给予血清素，导致平均动脉血压略有升高（分别为1%、4%和11%），子宫血流量大幅下降（分别为10%、37%和71%），但心输出量未改变。血清素导致子宫血管阻力增加，而全身血管阻力仅有微小变化（子宫血管阻力分别增加17%、107%和363%，而全身血管阻力分别增加3%、10%和11%）。相比之下，血管紧张素II增加了全身和子宫血管阻力（全身血管阻力分别增加16%、37%、56%和95%，子宫血管阻力分别增加5%、16%、28%和99%）。去甲肾上腺素也增加了全身和子宫血管阻力，不过程度不同（全身血管阻力分别增加5%、17%、37%和118%，子宫血管阻力分别增加5%、46%、84%和304%）。在妊娠晚期母羊中全身输注血清素会导致子宫血管收缩。与对子宫血管系统的显著作用相反，全身心血管反应较小，因此表明在所给予的剂量下血清素对子宫血管系统具有近乎选择性的作用。（摘要截断于250字）
