Yu Jun, Chen Chao, Wang Chen, Liu Lvye, Chen Hong, Li Hui, Liu Yongdi, Kuang Xingya
School of Resources and Environmental Engineering, East China University of Science and Technology, Shanghai, 200237, PR China.
Institute for Environmental Pollution and Health, School of Environmental and Chemical Engineering, Shanghai University, Shanghai, 200444, PR China.
Chemosphere. 2024 Jan;346:140549. doi: 10.1016/j.chemosphere.2023.140549. Epub 2023 Oct 25.
Ambient exposure to polychlorinated dibenzo-p-dioxins/furans (PCDD/Fs) is suspected to cause adverse human health outcomes. Herein, serum samples from 40 residents in the neighborhood of a municipal solid waste incinerator (MSWI) in the metropolitan area were measured for PCDD/Fs. The mean toxic equivalent (TEQ) concentration of total PCDD/Fs in human serum samples was 16.8 pg TEQ/g lipid. Serum PCDD/F levels were significantly higher in residents adjacent to the MSWI than in those from areas far from the emission source (p < 0.01). In addition, there were no significant associations between serum PCDD/Fs levels and factors, such as gender, age, and BMI in donors. For non-occupationally exposed populations, OCDD and 1,2,3,7,8-PeCDD in serum are available as indicators of total PCDD/Fs and total TEQ, respectively. The atmospheric PCDD/Fs levels were within a relatively low range in areas upwind and downwind of the MSWI. The results of the principal component analysis showed a distinct difference in PCDD/F congener patterns between air and serum samples, suggesting inhalation exposure could have a limited influence on the human body burden. Our findings will deepen the current knowledge of endogenous PCDD/F exposure in urban populations, and also facilitate public health protection strategies near MSWIs.
环境暴露于多氯二苯并 - 对二恶英/呋喃（PCDD/Fs）被怀疑会导致对人类健康产生不良影响。在此，对大都市地区一座城市固体废物焚烧炉（MSWI）附近40名居民的血清样本进行了PCDD/Fs检测。人类血清样本中总PCDD/Fs的平均毒性当量（TEQ）浓度为16.8 pg TEQ/g脂质。MSWI附近居民的血清PCDD/F水平显著高于远离排放源地区居民的水平（p < 0.01）。此外，血清PCDD/Fs水平与捐献者的性别、年龄和BMI等因素之间没有显著关联。对于非职业暴露人群，血清中的八氯二苯并 - 对二恶英（OCDD）和1,2,3,7,8 - 五氯二苯并 - 对二恶英（1,2,3,7,8 - PeCDD）分别可作为总PCDD/Fs和总TEQ的指标。在MSWI上风向和下风向区域，大气PCDD/Fs水平处于相对较低的范围。主成分分析结果表明，空气和血清样本中PCDD/F同系物模式存在明显差异，这表明吸入暴露对人体负担的影响可能有限。我们的研究结果将加深当前对城市人群内源性PCDD/F暴露的认识，也有助于制定MSWI附近的公共卫生保护策略。
