宿主对非结核分枝杆菌肺病的易感性。
Host Susceptibility to Nontuberculous Mycobacterial Pulmonary Disease.
机构信息
Department of Infectious Diseases, Keio University School of Medicine, 35 Shinanomachi Shinjyuku-ku, Tokyo 160-8582, Japan.
Division of Intramural Research, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), 10/11N248, MSC 1960, Bethesda, MD 20892-1960, USA.
出版信息
Clin Chest Med. 2023 Dec;44(4):723-730. doi: 10.1016/j.ccm.2023.07.002. Epub 2023 Aug 21.
Abstract
Nontuberculous mycobacteria (NTM) pulmonary disease is a chronic progressive pulmonary infectious disease caused by low virulence pathogens. The existence of host susceptibility to NTM infection has been recognized from a high incidence among Asians compared to other populations in the United States, a high incidence among slender, middle-aged women, and the presence of familial clusters. Recent whole exome sequencing and genome-wide association studies have identified immune, CFTR, cilia, connective tissue and ion homeostasis genes as host susceptibility genes. Large-scale international collaborative studies and functional analyses are expected to elucidate host susceptibility in the future.
摘要
非结核分枝杆菌（NTM）肺病是一种由低毒力病原体引起的慢性进行性肺部传染病。从美国的人群比较中可以看出，宿主对 NTM 感染的易感性，与亚洲人群相比，美国人群中 NTM 的发病率较高，发病率较高的是身材苗条的中年女性，而且存在家族聚集现象。最近的全外显子组测序和全基因组关联研究已经确定了免疫、CFTR、纤毛、结缔组织和离子稳态基因作为宿主易感性基因。预计未来将进行大规模的国际合作研究和功能分析，以阐明宿主的易感性。
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