Emerg Infect Dis. 2022 Aug;28(8):1543-1550. doi: 10.3201/eid2808.212375.
To further clarify differences in the risk for nontuberculous mycobacterial pulmonary infection (NTM-PI) among ethnic populations in Hawaii, USA, we conducted a retrospective cohort study among beneficiaries of Kaiser Permanente Hawaii (KPH). We abstracted demographic, socioeconomic, clinical, and microbiological data from KPH electronic health records for 2005-2019. An NTM-PI case-patient was defined as a person from whom >1 NTM pulmonary isolate was obtained. We performed Cox proportional hazards regression to estimate incidence of NTM-PI while controlling for confounders. Across ethnic groups, risk for NTM-PI was higher among persons who were underweight (body mass index [BMI] <18.5 kg/m). Among beneficiaries who self-identified as any Asian ethnicity, risk for incident NTM-PI was increased by 30%. Low BMI may increase susceptibility to NTM-PI, and risk may be higher for persons who self-identify as Asian, independent of BMI.
为了进一步阐明美国夏威夷不同族裔人群中非结核分枝杆菌肺部感染（NTM-PI）的风险差异，我们对 Kaiser Permanente Hawaii（KPH）的受益人群进行了回顾性队列研究。我们从 KPH 的电子健康记录中提取了 2005-2019 年的人口统计学、社会经济、临床和微生物学数据。NTM-PI 病例患者被定义为从其体内分离出>1 株 NTM 肺部分离株的人。我们通过 Cox 比例风险回归来估计 NTM-PI 的发病率，同时控制混杂因素。在各个族裔群体中，体重不足（BMI<18.5kg/m）的人群发生 NTM-PI 的风险更高。在自我认定为任何亚洲族裔的受益人群中，发生 NTM-PI 的风险增加了 30%。低 BMI 可能会增加对 NTM-PI 的易感性，而无论 BMI 如何，自我认定为亚洲人的人群的风险可能更高。
