Department of Oral and Maxillofacial Diseases, Helsinki University and University Hospital, Helsinki, Finland.
Department of Preventive Dental Sciences, College of Dentistry, Majmaah University, Al-Majmaah, Saudi Arabia.
Oral Dis. 2024 Jul;30(5):2784-2796. doi: 10.1111/odi.14769. Epub 2023 Oct 27.
The systematic review aimed to compare the levels of advanced glycation end products (AGEs) and RAGE (AGE receptors) expression in diabetic periodontitis patients with non-diabetic periodontitis patients and to identify the relationship of AGE and RAGE levels with periodontal disease severity.
The literature search was carried out according to PRISMA guidelines by two independent researchers using four online databases: PubMed, Scopus, Web of Science Core Collection, and Pro-Quest. Relevant studies published between 2000 and March 2023 were included in this review. The association of diabetes and AGE/RAGE levels on periodontal health, periodontal pocket depth (PPD), and clinical attachment loss (CAL) was studied.
Sixteen cross-sectional studies, including 2794 patients (age range 15-75 years), were identified in the final stage. An elevated AGE level was observed among patients with diabetes and chronic periodontal disease compared to the non-diabetic group. Furthermore, the levels of AGE and RAGE are associated with CAL and PPD. Potential confounding factors like genetic and methodological differences were also responsible for AGE and RAGE variation.
Levels of AGEs and RAGE expressions in diabetic periodontitis patients differ from non-diabetic periodontitis patients. The differences may impact the course and severity of periodontal disease.
本系统评价旨在比较糖尿病性牙周炎患者与非糖尿病性牙周炎患者的晚期糖基化终产物（AGEs）和 RAGE（AGE 受体）表达水平，并确定 AGE 和 RAGE 水平与牙周病严重程度的关系。
两名独立研究人员按照 PRISMA 指南，使用四个在线数据库（PubMed、Scopus、Web of Science Core Collection 和 Pro-Quest）进行文献检索。本综述纳入了 2000 年至 2023 年 3 月期间发表的相关研究。研究了糖尿病与 AGE/RAGE 水平对牙周健康、牙周袋深度（PPD）和临床附着丧失（CAL）的影响。
最终阶段确定了 16 项横断面研究，共纳入 2794 名患者（年龄范围 15-75 岁）。与非糖尿病组相比，糖尿病伴慢性牙周病患者的 AGE 水平升高。此外，AGE 和 RAGE 水平与 CAL 和 PPD 相关。遗传和方法学差异等潜在混杂因素也是导致 AGE 和 RAGE 变化的原因。
糖尿病性牙周炎患者的 AGEs 和 RAGE 表达水平与非糖尿病性牙周炎患者不同。这些差异可能影响牙周病的病程和严重程度。
