Jiang Huadong, Chan Ying Wai
School of Biological Sciences, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region of China.
School of Biological Sciences, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region of China.
Trends Genet. 2024 Jan;40(1):69-82. doi: 10.1016/j.tig.2023.10.004. Epub 2023 Oct 25.
Genetic material is organized in the form of chromosomes, which need to be segregated accurately into two daughter cells in each cell cycle. However, chromosome fusion or the presence of unresolved interchromosomal linkages lead to the formation of chromatin bridges, which can induce DNA lesions and genome instability. Persistent chromatin bridges are trapped in the cleavage furrow and are broken at or after abscission, the final step of cytokinesis. In this review, we focus on recent progress in understanding the mechanism of bridge breakage and resolution. We discuss the molecular machinery and enzymes that have been implicated in the breakage and processing of bridge DNA. In addition, we outline both the immediate outcomes and genomic consequences induced by bridge breakage.
遗传物质以染色体的形式组织，在每个细胞周期中需要准确地分离到两个子细胞中。然而，染色体融合或未解决的染色体间连接的存在会导致染色质桥的形成，这会诱导DNA损伤和基因组不稳定。持续存在的染色质桥被困在分裂沟中，并在胞质分裂的最后一步——脱落时或之后断裂。在这篇综述中，我们关注在理解桥断裂和解决机制方面的最新进展。我们讨论了与桥DNA的断裂和加工有关的分子机制和酶。此外，我们概述了桥断裂所诱导的直接结果和基因组后果。
