Neri Iria, Galeone Carlotta, Pelucchi Claudio, Ronci Gianluca, Matruglio Paolo, Pedone Maria Paola, Galli Elena
Dermatology Unit, IRCCS Azienda Ospedaliero Universitaria di Bologna, University of Bologna, 40138 Bologna, Italy.
Department of Statistics, Bicocca Applied Statistics Center (B-ASC), Università degli Studi di Milano-Bicocca, 20126 Milan, Italy.
Children (Basel). 2023 Sep 29;10(10):1629. doi: 10.3390/children10101629.
Atopic dermatitis (AD) is one of the most common diseases worldwide. Severe AD has a major impact on the quality of life of patients. We performed a systematic literature review on the epidemiology of AD in Italian pre-school children (age 0-5 years) and we assessed the available data on the severity of AD. In August 2022, we performed a bibliographic search using PubMed/Medline and EMBASE. We identified 10 studies with Italian data on the prevalence and/or incidence of AD in pre-school children. The period (12 months) prevalence of AD varied widely across studies, ranging between 4.0% and 42.2%, with median estimates of 14.3% among all studies and 11.8% among studies from 2010 onwards. Applied to the Italian population, this leads to a prevalence of 309,000-375,000 pre-school AD cases. Only one study computed the incidence of AD, reporting rates of 9 cases per 100 person-years in children aged 0-1 year, and 2.5 cases per 100 person-years in children aged 1-4 years. Severity data from Italy were also reviewed, across three identified three studies. A point estimate found 8.4% of cases were considered severe in one study based on the Patient-Oriented Eczema Measure (POEM), with an overall range of 7.8-11% across different Italian studies and according to various severity score types.
特应性皮炎（AD）是全球最常见的疾病之一。重度AD对患者的生活质量有重大影响。我们对意大利学龄前儿童（0至5岁）AD的流行病学进行了系统的文献综述，并评估了有关AD严重程度的现有数据。2022年8月，我们使用PubMed/Medline和EMBASE进行了文献检索。我们确定了10项有关意大利学龄前儿童AD患病率和/或发病率的数据研究。AD的12个月患病率在各项研究中差异很大，介于4.0%至42.2%之间，所有研究的中位数估计为14.3%，2010年以后的研究为11.8%。应用于意大利人口，这导致学龄前AD病例的患病率为309,000 - 375,000例。只有一项研究计算了AD的发病率，报告0至1岁儿童的发病率为每100人年9例，1至4岁儿童为每100人年2.5例。我们还对来自意大利的三项已确定研究中的严重程度数据进行了综述。一项基于患者导向性湿疹量表（POEM）的研究发现，8.4%的病例被认为是重度，在不同的意大利研究中，根据各种严重程度评分类型，总体范围为7.8% - 11%。
