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儿童Blount病手术治疗的复发率和并发症发生率:一项系统评价和Meta分析

Recurrence and Complication Rates of Surgical Treatment for Blount's Disease in Children: A Systematic Review and Meta-Analysis.

作者信息

Ramella Marco, Depaoli Alessandro, Menozzi Grazia Chiara, Gallone Giovanni, Cerasoli Tosca, Rocca Gino, Trisolino Giovanni

机构信息

Unit of Pediatric Orthopedics and Traumatology, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, Italy.

出版信息

J Clin Med. 2023 Oct 12;12(20):6495. doi: 10.3390/jcm12206495.

Abstract

BACKGROUND

Blount's disease is a growth disorder of the proximal tibia that causes progressive genu varum in children. Surgical treatment is recommended if the deformity worsens, but which intervention is best remains controversial. This study aims to identify factors influencing outcomes and determine the most effective surgical approach.

METHODS

A systematic review was conducted of studies published before January 2022.

RESULTS

In total, 63 retrospective studies with CEBM IIIb/IV levels were included (1672 knees in 1234 patients). The most commonly reported treatment was acute correction via osteotomy (47%), followed by hemiepiphysiodesis (22%) and gradual correction (18%). Combined procedures were reported in 13% of cases. The overall recurrence rate was 18%, with a significant difference when comparing the recurrence rates after gradual correction with those after hemiepiphysiodesis (7% and 29%, respectively). Major complications beyond recurrence were observed in 5% of cases. A meta-analysis of the available raw data showed a significantly increased recurrence rate (39%) among treated children who were between 4.5 and 11.25 years of age and were followed for a minimum follow-up of 2.5 years.

CONCLUSIONS

Overall, poor evidence with which to establish an optimal treatment for Blount's disease was found. This study remarked on the need for early diagnosis, classification, and treatment of infantile tibia vara, since a significant rate of recurrence was found in neglected cases.

摘要

背景

布朗特病是一种胫骨近端的生长紊乱疾病,可导致儿童进行性膝内翻。如果畸形加重,建议进行手术治疗,但哪种干预措施最佳仍存在争议。本研究旨在确定影响治疗结果的因素,并确定最有效的手术方法。

方法

对2022年1月前发表的研究进行系统评价。

结果

共纳入63项CEBM IIIb/IV级的回顾性研究(1234例患者中的1672个膝关节)。最常报道的治疗方法是截骨术急性矫正(47%),其次是半骨骺阻滞术(22%)和逐步矫正(18%)。13%的病例报道了联合手术。总体复发率为18%,逐步矫正后的复发率与半骨骺阻滞术后的复发率相比有显著差异(分别为7%和29%)。5%的病例观察到除复发外的主要并发症。对现有原始数据的荟萃分析显示,在4.5至11.25岁且至少随访2.5年的接受治疗儿童中,复发率显著增加(39%)。

结论

总体而言,发现用于确定布朗特病最佳治疗方法的证据不足。本研究指出了对婴儿型胫骨内翻进行早期诊断、分类和治疗的必要性,因为在被忽视的病例中发现了较高的复发率。

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