McKay Tina B, Emmitte Kyle A, German Carrie, Karamichos Dimitrios
Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.
Department of Pharmaceutical Sciences, UNT System College of Pharmacy, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.
Bioengineering (Basel). 2023 Sep 25;10(10):1127. doi: 10.3390/bioengineering10101127.
Quercetin is a polyphenol of the flavonoid class of secondary metabolites that is widely distributed in the plant kingdom. Quercetin has been found to exhibit potent bioactivity in the areas of wound healing, neuroprotection, and anti-aging research. Naturally found in highly glycosylated forms, aglycone quercetin has low solubility in aqueous environments, which has heavily limited its clinical applications. To improve the stability and bioavailability of quercetin, efforts have been made to chemically modify quercetin and related flavonoids so as to improve aqueous solubility while retaining bioactivity. In this review, we provide an updated overview of the biological properties of quercetin and proposed mechanisms of actions in the context of wound healing and aging. We also provide a description of recent developments in synthetic approaches to improve the solubility and stability of quercetin and related analogs for therapeutic applications. Further research in these areas is expected to enable translational applications to improve ocular wound healing and tissue repair.
槲皮素是次生代谢产物黄酮类中的一种多酚，广泛分布于植物界。已发现槲皮素在伤口愈合、神经保护和抗衰老研究领域具有强大的生物活性。天然存在的槲皮素以高度糖基化形式存在，其苷元在水性环境中的溶解度较低，这严重限制了其临床应用。为提高槲皮素的稳定性和生物利用度，人们已致力于对槲皮素及相关黄酮类进行化学修饰，以提高其在水中的溶解度，同时保留生物活性。在本综述中，我们提供了槲皮素生物学特性的最新概述，以及在伤口愈合和衰老背景下的作用机制。我们还描述了在合成方法方面的最新进展，以改善槲皮素及相关类似物的溶解度和稳定性，用于治疗应用。预计在这些领域的进一步研究将实现转化应用，以改善眼部伤口愈合和组织修复。
