Tur Bogac, Gühring Lucia, Wendler Olaf, Schlicht Samuel, Drummer Dietmar, Kniesburges Stefan
Division of Phoniatrics and Pediatric Audiology, Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Erlangen, Medical School, Friedrich-Alexander-Universität Erlangen-Nürnberg, Waldstrasse 1, 91054 Erlangen, Germany.
Institute of Polymer Technology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Am Weichselgarten 10, 91058 Erlangen, Germany.
Bioengineering (Basel). 2023 Sep 26;10(10):1130. doi: 10.3390/bioengineering10101130.
Synthetic silicone larynx models are essential for understanding the biomechanics of physiological and pathological vocal fold vibrations. The aim of this study is to investigate the effects of artificial ligament fibers on vocal fold vibrations in a synthetic larynx model, which is capable of replicating physiological laryngeal functions such as elongation, abduction, and adduction. A multi-layer silicone model with different mechanical properties for the musculus vocalis and the lamina propria consisting of ligament and mucosa was used. Ligament fibers of various diameters and break resistances were cast into the vocal folds and tested at different tension levels. An electromechanical setup was developed to mimic laryngeal physiology. The measurements included high-speed video recordings of vocal fold vibrations, subglottal pressure and acoustic. For the evaluation of the vibration characteristics, all measured values were evaluated and compared with parameters from ex and in vivo studies. The fundamental frequency of the synthetic larynx model was found to be approximately 200-520 Hz depending on integrated fiber types and tension levels. This range of the fundamental frequency corresponds to the reproduction of a female normal and singing voice range. The investigated voice parameters from vocal fold vibration, acoustics, and subglottal pressure were within normal value ranges from ex and in vivo studies. The integration of ligament fibers leads to an increase in the fundamental frequency with increasing airflow, while the tensioning of the ligament fibers remains constant. In addition, a tension increase in the fibers also generates a rise in the fundamental frequency delivering the physiological expectation of the dynamic behavior of vocal folds.
合成硅胶喉模型对于理解生理和病理状态下声带振动的生物力学至关重要。本研究的目的是在一个能够复制诸如伸长、外展和内收等生理喉功能的合成喉模型中，研究人工韧带纤维对声带振动的影响。使用了一种多层硅胶模型，其声带肌和由韧带及黏膜组成的固有层具有不同的力学性能。将不同直径和抗断裂强度的韧带纤维铸入声带，并在不同张力水平下进行测试。开发了一种机电装置来模拟喉生理。测量包括声带振动的高速视频记录、声门下压力和声信号。为了评估振动特性，对所有测量值进行了评估，并与体外和体内研究的参数进行了比较。发现合成喉模型的基频约为200 - 520赫兹，这取决于所整合的纤维类型和张力水平。这个基频范围对应于女性正常和歌唱声音范围的再现。从声带振动、声学和声门下压力研究的语音参数在体外和体内研究的正常值范围内。韧带纤维的整合导致随着气流增加基频升高，而韧带纤维的张紧保持不变。此外，纤维张力的增加也会使基频升高，这符合声带动态行为的生理预期。
