Janning Anna, Lademann Hanne, Olbertz Dirk
Department for Pediatrics, Universitätsklinikum Würzburg, 97070 Würzburg, Bavaria, Germany.
Department of Pediatrics, University Rostock, 18057 Rostock, Mecklenburg-Vorpommern, Germany.
Biomedicines. 2023 Sep 25;11(10):2626. doi: 10.3390/biomedicines11102626.
Early diagnosis of developmental delays is essential to providing early developmental care. The Münchener Funktionelle Entwicklungsdiagnostik (MFED) is a simple and cost-effective tool for diagnosing the development of infants and young children. Nevertheless, the MFED has not been a well-studied part of current research. This retrospective cohort study aims to detect risk factors and assess the impact of developmental care during the first twelve months of life, using the MFED. Furthermore, it determines the MFED's predictive value by comparing results with an international gold standard, the Bayley Scales of Infant Development II (BSID II). The study included 303 infants born between 2008-2013 in Rostock, Germany, with a birth weight of ≤1500 g and/or a gestational age of ≤32 weeks, who were evaluated with the MFED at twelve months of age. To ascertain the predictive value, 213 infants underwent BSID II assessment at 24 months of age. Intraventricular hemorrhage (IVH), necrotizing enterocolitis (NEC), and periventricular leukomalacia (PVL) were significantly associated with a higher risk of developmental delay across various domains. Post-discharge developmental care therapies did not indicate any clear beneficial effect on the infant's development. Nevertheless, some domains of MFED demonstrate predictive value, warranting increased attention for this diagnostic.
发育迟缓的早期诊断对于提供早期发育护理至关重要。慕尼黑功能性发育诊断法(MFED)是一种用于诊断婴幼儿发育的简单且经济高效的工具。然而,MFED尚未成为当前研究中经过充分研究的部分。这项回顾性队列研究旨在利用MFED检测风险因素并评估生命最初十二个月期间发育护理的影响。此外,通过将结果与国际金标准贝利婴幼儿发育量表第二版(BSID II)进行比较,确定MFED的预测价值。该研究纳入了2008年至2013年在德国罗斯托克出生的303名婴儿,出生体重≤1500克和/或胎龄≤32周,这些婴儿在12个月大时接受了MFED评估。为确定预测价值,213名婴儿在24个月大时接受了BSID II评估。脑室内出血(IVH)、坏死性小肠结肠炎(NEC)和脑室周围白质软化(PVL)与各个领域发育迟缓的较高风险显著相关。出院后的发育护理治疗对婴儿发育未显示出任何明显的有益效果。然而,MFED的某些领域显示出预测价值,值得对这种诊断给予更多关注。