Bonadies Antonio, Iorio Alessandra, Silipo Vitaliano, Cota Carlo, Govoni Flavio Andrea, Battista Michela, Pallara Tiziano, Migliano Emilia
Department of Plastic and Regenerative Surgery, San Gallicano Dermatological Institute-IRCCS, 00144 Rome, Italy.
Department of Oncologic and Preventative Dermatology, San Gallicano Dermatological Institute-IRCCS, 00144 Rome, Italy.
Biomedicines. 2023 Sep 28;11(10):2667. doi: 10.3390/biomedicines11102667.
Brooke-Spiegler syndrome is a rare autosomal dominant disorder characterized by the continuous development of multiple benign skin appendage tumors. It is treated usually by repeated standard surgery. Here, we present a case study where electrochemotherapy (ECT) with bleomycin was used as an effective alternative approach in treating advanced dermal cylindromatosis of the head and neck in a patient with Brooke-Spiegler syndrome.
A 45-year-old woman presented with multiple recurrent dermal cylindroma lesions on her scalp. Previous treatment consisted of several surgical excisions that resulted in psychological deterioration due to the formation of numerous scars and extensive alopecic areas. ECT was offered to provide tumor removal and disease control and to improve the patient's quality of life.
The treatment was well tolerated, and a significant reduction in neoplastic tissue was achieved. Importantly, scalp skin condition significantly improved, regaining a fair follicular density on the margins.
This report suggests the feasibility of bleomycin ECT as a less invasive alternative option for controlling multiple scalp cylindroma lesions with cosmetically acceptable results, and improving quality of life.
布鲁克 - 施皮格勒综合征是一种罕见的常染色体显性疾病，其特征为多发性良性皮肤附属器肿瘤持续发生。通常采用反复的标准手术进行治疗。在此，我们报告一例病例，其中使用博来霉素进行电化学疗法（ECT）作为一种有效的替代方法，用于治疗一名布鲁克 - 施皮格勒综合征患者的头颈部晚期皮肤圆柱瘤病。
一名45岁女性，头皮出现多发性复发性皮肤圆柱瘤病变。先前的治疗包括多次手术切除，但由于形成大量瘢痕和广泛脱发区，导致心理状况恶化。提供ECT以切除肿瘤并控制疾病，改善患者生活质量。
治疗耐受性良好，肿瘤组织显著减少。重要的是，头皮皮肤状况明显改善，边缘毛囊密度恢复良好。
本报告表明，博来霉素ECT作为一种侵入性较小的替代选择，用于控制多发性头皮圆柱瘤病变并获得美容可接受的结果以及改善生活质量是可行的。
