Department of Dermatology and Allergology, University of Szeged, Szeged, Hungary.
Department of Ophthalmology, University of Szeged, Szeged, Hungary.
Sci Rep. 2019 Mar 12;9(1):4285. doi: 10.1038/s41598-019-41026-2.
There is increasing evidence about the effectiveness of electrochemotherapy (ECT) in the treatment of basal cell carcinomas in the head and neck region, although its role in the management of eyelid-periocular skin tumors has to be clarified. The aim of the present study is to evaluate the results of ECT in the treatment of locally advanced primary and recurrent eyelid-periocular skin basal cell carcinomas. Twelve patients with basal cell carcinoma involving the eyelid-periocular skin region were treated with ECT. Three patients had locally advanced primary tumors, while 9 patients had recurrent tumors. All treatments were performed according to the ESOPE guidelines, using Cliniporator TM device. All patients received bleomycin based ECT. The route of administration was intratumoral in 3 patients and intravenous in 9 patients. Tumor response was evaluated using the RECIST 1.1. criteria. ECT resulted in complete response of the periocular skin tumors in all patients. Lower eyelid ectropion was developed in 3 patients which had to be corrected surgically. ECT can be used effectively in the treatment of locally advanced or recurrent basal cell carcinomas in the eyelid-periocular skin region. Excellent tumor control can be achieved with good functional and cosmetic results without systemic adverse events with short interval follow-up.
越来越多的证据表明电化学疗法（ECT）在治疗头颈部基底细胞癌方面的有效性，尽管其在眼睑-眶周皮肤肿瘤治疗中的作用尚需阐明。本研究旨在评估 ECT 治疗局部晚期原发性和复发性眼睑-眶周皮肤基底细胞癌的疗效。12 例累及眼睑-眶周皮肤的基底细胞癌患者接受 ECT 治疗。3 例为局部晚期原发性肿瘤，9 例为复发性肿瘤。所有治疗均按照 ESOPE 指南进行，使用 Cliniporator TM 设备。所有患者均接受博来霉素为基础的 ECT。3 例患者采用瘤内途径，9 例患者采用静脉途径。采用 RECIST 1.1 标准评估肿瘤反应。ECT 使所有患者的眶周皮肤肿瘤完全缓解。3 例患者出现下眼睑外翻，需要手术矫正。ECT 可有效治疗眼睑-眶周皮肤的局部晚期或复发性基底细胞癌。在短时间随访中，可获得良好的功能和美容效果，无全身不良反应，实现良好的肿瘤控制。
