Haroon Faisal, Farwa Umme, Arif Maimoona, Raza Muhammad Asam, Sandhu Zeshan Ali, El Oirdi Mohamed, Farhan Mohd, Alhasawi Mohammed Ahmed Ismail
Department of Basic Sciences, Preparatory Year Deanship, King Faisal University, Al-Ahsa 31982, Saudi Arabia.
Department of Chemistry, Hafiz Hayat Campus, University of Gujrat, Gujrat 50700, Pakistan.
Biomedicines. 2023 Sep 30;11(10):2686. doi: 10.3390/biomedicines11102686.
A "building block" is a key component that plays a substantial and critical function in the pharmaceutical research and development industry. Given its structural versatility and ability to undergo substitutions at both the amino and carboxyl groups, para-aminobenzoic acid (PABA) is a commonly used building block in pharmaceuticals. Therefore, it is great for the development of a wide range of novel molecules with potential medical applications. Anticancer, anti-Alzheimer's, antibacterial, antiviral, antioxidant, and anti-inflammatory properties have been observed in PABA compounds, suggesting their potential as therapeutic agents in future clinical trials. PABA-based therapeutic chemicals as molecular targets and their usage in biological processes are the primary focus of this review study. PABA's unique features make it a strong candidate for inclusion in a massive chemical database of molecules having drug-like effects. Based on the current literature, further investigation is needed to evaluate the safety and efficacy of PABA derivatives in clinical investigations and better understand the specific mechanism of action revealed by these compounds.
“构建模块”是在制药研发行业中发挥重要且关键作用的关键成分。鉴于对氨基苯甲酸（PABA）具有结构多样性以及在氨基和羧基处均可进行取代的能力，它是制药领域常用的构建模块。因此，它非常有利于开发具有潜在医学应用价值的多种新型分子。在PABA化合物中已观察到抗癌、抗阿尔茨海默病、抗菌、抗病毒、抗氧化和抗炎特性，这表明它们在未来临床试验中具有作为治疗剂的潜力。基于PABA的治疗性化学物质作为分子靶点及其在生物过程中的用途是本综述研究的主要重点。PABA的独特特性使其成为纳入具有类药物作用的大量分子化学数据库的有力候选者。基于当前文献，需要进一步研究以评估PABA衍生物在临床研究中的安全性和有效性，并更好地理解这些化合物所揭示的具体作用机制。
