Petersson G, Dreborg S, Ingestad R
Allergy. 1986 Aug;41(6):398-407. doi: 10.1111/j.1398-9995.1986.tb00319.x.
The diagnostic efficacy of clinical history (CH), skin prick test (SPT) and RAST was estimated in relation to nasal and conjunctival provocation tests (NPT, CPT) in 69 patients with seasonal rhinoconjunctivitis. The extracts used were freeze-dried, and biologically standardized birch and timothy allergen preparations matched to the extracts on Phadebas RAST discs. Based on single determinations the sensitivity, specificity and predictive values were calculated. There were highly significant (P less than 0.001) correlations between all parameters: NPT, CPT, CH, SPT and RAST. For birch the combination of SPT and RAST made the PTs superfluous as both sensitivity and specificity then reached 100%. With timothy the sensitivity was 97% and with the addition of CH 100%. However, the specificity was only 79% through combining CH, SPT and RAST. The present study using the same standardized allergen preparation in all tests showed a good correlation between indirect test results and provocation tests.
对69例季节性鼻结膜炎患者，评估了临床病史（CH）、皮肤点刺试验（SPT）和放射性变应原吸附试验（RAST）相对于鼻和结膜激发试验（NPT、CPT）的诊断效能。所用提取物为冻干的、生物标准化的桦树和梯牧草过敏原制剂，与法玛西亚RAST圆盘上的提取物相匹配。根据单次测定结果计算敏感性、特异性和预测值。所有参数（NPT、CPT、CH、SPT和RAST）之间存在高度显著（P＜0.001）的相关性。对于桦树，SPT和RAST的联合使用使激发试验变得多余，因为此时敏感性和特异性均达到100%。对于梯牧草，敏感性为97%，加入CH后为100%。然而，通过联合CH、SPT和RAST，特异性仅为79%。本研究在所有试验中使用相同的标准化过敏原制剂，结果显示间接试验结果与激发试验之间具有良好的相关性。
