The Clinic of Rheumatology, Traumatology Orthopaedics and Reconstructive Surgery, Institute of Clinical Medicine of the Faculty of Vilnius University, M. K. Čiurlionio Str. 21, 03101 Vilnius, Lithuania.
State Research Institute Centre for Innovative Medicine, Santariškių g. 5, 08406 Vilnius, Lithuania.
Medicina (Kaunas). 2023 Oct 13;59(10):1824. doi: 10.3390/medicina59101824.
: About 40% of early undifferentiated arthritis (UA) progresses to rheumatoid (RA) or other chronic arthritis. Novel diagnostic tools predicting the risk for this progression are needed to identify the patients who would benefit from early aggressive treatment. Evidence on the role of single-nucleotide polymorphisms (SNPs) in the development of RA has emerged. The aim of our study was to investigate the association between rs2476601, rs833070, and rs6920220 SNPs and UA progression to RA. : Ninety-two UA patients were observed for 12 months. At study entry, demographic and clinical characteristics were recorded, musculoskeletal ultrasonography was performed, and blood samples were drawn to investigate levels of inflammatory markers, rheumatoid factor (RF), anti-citrullinated protein antibodies (anti-CCP)detect SNPs. After 12 months, UA outcomes were assessed, and patients were divided into two (RA and non-RA) groups. The association between the risk of progression to chronic inflammatory arthritis and analyzed SNPs was measured by computing odds ratios (OR). : After a 12-month follow-up, 27 (29.3%) patients developed RA, and 65 (70.7%) patients were assigned to the non-RA group. The arthritis of 21 patients (22.8%) from the non-RA group resolved completely, while the other 44 (47.2%) patients were diagnosed with another rheumatic inflammatory disease. The patients who developed RA had a significantly greater number of tender and swollen joints ( = 0.010 and = 0.021 respectively) and were more frequently RF or anti-CCP ( < 0.001), and both RF and anti-CCP positive ( < 0.001) at the baseline as compared with the patients in the non-RA group. No significant association between rs2476601 (OR = 0.99, = 0.98), rs833070 (OR = 1.0, = 0.97), and rs6920220 (OR = 0.48, = 0.13) polymorphisms and the risk of developing RA were found. : No association between analyzed SNPs and a greater risk to progress from UA to RA was confirmed, although patients with rs6920220 + genotypes had fewer tender joints at the disease onset.
约 40%的早期未分化关节炎 (UA) 会进展为类风湿性关节炎 (RA) 或其他慢性关节炎。需要新型的诊断工具来预测这种进展的风险，以确定哪些患者将受益于早期积极治疗。单核苷酸多态性 (SNP) 在 RA 发展中的作用的证据已经出现。本研究的目的是探讨 rs2476601、rs833070 和 rs6920220 单核苷酸多态性与 UA 进展为 RA 之间的关系。
92 例 UA 患者观察 12 个月。在研究开始时，记录人口统计学和临床特征，进行肌肉骨骼超声检查，并抽取血液样本以调查炎症标志物、类风湿因子 (RF)、抗瓜氨酸蛋白抗体 (抗 CCP) 的水平，以检测 SNPs。12 个月后，评估 UA 结局，并将患者分为两组 (RA 和非 RA)。通过计算比值比 (OR) 来衡量分析 SNPs 与进展为慢性炎症性关节炎的风险之间的关系。
经过 12 个月的随访，27 例 (29.3%)患者发展为 RA，65 例 (70.7%)患者被归入非 RA 组。非 RA 组中 21 例 (22.8%)患者的关节炎完全缓解，而其余 44 例 (47.2%)患者被诊断为另一种风湿性炎症性疾病。与非 RA 组相比，发生 RA 的患者的压痛关节和肿胀关节数量明显更多 (分别为 = 0.010 和 = 0.021)，且 RF 或抗 CCP 更频繁阳性 ( < 0.001)，RF 和抗 CCP 均阳性 ( < 0.001)。基线时。
未发现 rs2476601 (OR = 0.99， = 0.98)、rs833070 (OR = 1.0， = 0.97)和 rs6920220 (OR = 0.48， = 0.13) 多态性与发生 RA 的风险之间存在显著关联。
尽管 rs6920220 + 基因型患者在发病时压痛关节较少，但分析的 SNPs 与从 UA 进展为 RA 的风险增加之间没有关联得到证实。
