Department of Hematology, Faculty of Medical Laboratory Sciences, Port Sudan Ahlia College, Port Sudan 33312, Sudan.
Department of Hematology, Faculty of Medical Laboratory Science, National University, Khartoum 11111, Sudan.
Medicina (Kaunas). 2023 Oct 13;59(10):1826. doi: 10.3390/medicina59101826.
HIV disease is recognized to cause inconsistencies in coagulation via various pathways during infection. Some studies have indicated that HIV-infected patients are prone to developing thrombocytopenia, thrombosis, or autoantibodies that may cause difficulties in diagnosis. This study is intended to measure the trend of coagulation parameters in Sudanese patients with HIV. A cross-sectional study was carried out in patients with HIV admitted to the Sudan National AIDS Program (SNAP) from January 2018 to December 2019. Prothrombin time (PT), partial thromboplastin time (PTT), thrombin time (TT), D-dimer (DD), hemoglobin (HB), total lymphocyte count (TLC), platelet count (PLT), and a disintegrin and metalloproteinase with thrombospondin type 1 motif, member 13 (ADAMTS13), were evaluated among HIV Sudanese patients. Out of the 44 HIV patients included, 6 (13.6%) were found to have thrombotic thrombocytopenic purpura-like events and 12 (27.2%) had antiphospholipid antibodies, of whom 8 (66.6%) showed anticardiolipin antibody (1gG (75%) and IgM (25%)) and 4 showed lupus anticoagulants. The HB, TLC, and PLT values were found to be significantly lower in HIV patients than in control ( = 0.000, 0.000, and 0.050, respectively). The PT and ADAMTS13 values showed no significant difference between HIV patients and control ( = 0.613 and 0.266, respectively). The PTT, TT, and DD values were found to be augmented in HIV patients versus the control ( = 0.000). Thrombotic thrombocytopenic purpura-like events among HIV Sudanese patients were explored. In addition, antiphospholipid antibodies were strikingly seen in these patients. Additional research is anticipated to confirm these diagnoses.
艾滋病毒疾病被认为会通过感染过程中的各种途径导致凝血的不一致。一些研究表明，艾滋病毒感染患者容易发生血小板减少症、血栓形成或自身抗体，这可能导致诊断困难。本研究旨在测量苏丹艾滋病毒患者的凝血参数趋势。对 2018 年 1 月至 2019 年 12 月期间在苏丹国家艾滋病规划署（SNAP）就诊的艾滋病毒患者进行了横断面研究。评估了艾滋病毒苏丹患者的凝血酶原时间（PT）、部分凝血活酶时间（PTT）、凝血酶时间（TT）、D-二聚体（DD）、血红蛋白（HB）、总淋巴细胞计数（TLC）、血小板计数（PLT）和去整合素金属蛋白酶与血小板反应蛋白 1 型，成员 13（ADAMTS13）。在 44 名艾滋病毒患者中，有 6 名（13.6%）被发现患有血栓性血小板减少性紫癜样事件，12 名（27.2%）有抗磷脂抗体，其中 8 名（66.6%）显示抗心磷脂抗体（1gG（75%）和 IgM（25%）），4 名显示狼疮抗凝剂。与对照组相比，艾滋病毒患者的 HB、TLC 和 PLT 值明显较低（=0.000、0.000 和 0.050）。艾滋病毒患者和对照组之间的 PT 和 ADAMTS13 值无显著差异（=0.613 和 0.266）。与对照组相比，艾滋病毒患者的 PTT、TT 和 DD 值增加（=0.000）。探索了艾滋病毒苏丹患者的血栓性血小板减少性紫癜样事件。此外，这些患者明显出现抗磷脂抗体。预计将进行更多研究以确认这些诊断。
