Tan Yong-Zhen, Shi Rong-Jia, Ke Bo-Wen, Tang Ya-Ling, Liang Xin-Hua
State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Laboratory of Anesthesiology & Critical Care Medicine, Translational Neuroscience Center, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.
Heliyon. 2023 Jul 7;9(7):e18031. doi: 10.1016/j.heliyon.2023.e18031. eCollection 2023 Jul.
Local anesthetics are frequently used by dentists to relieve localized discomfort of the patient and improve treatment conditions. The risk of paresthesia after local anesthesia is frequently encountered in dental clinics. The neurotoxicity of local anesthetics is a disregarded factor in paresthesia. The review summarizes the types of common local anesthetics, incidence and influencing factors of paresthesia after local anesthesia, and systematically describes the neurotoxicity mechanisms of dental local anesthetic. Innovative strategies may be developed to lessen the neurotoxicity and prevent paresthesia following local anesthesia with the support of a substantial understanding of paresthesia and neurotoxicity.
牙医经常使用局部麻醉剂来缓解患者的局部不适并改善治疗条件。牙科诊所中经常会遇到局部麻醉后感觉异常的风险。局部麻醉剂的神经毒性是感觉异常中一个被忽视的因素。这篇综述总结了常见局部麻醉剂的类型、局部麻醉后感觉异常的发生率及影响因素，并系统描述了牙科局部麻醉剂的神经毒性机制。在充分了解感觉异常和神经毒性的支持下，可能会制定创新策略来减轻神经毒性并预防局部麻醉后的感觉异常。
