烧伤后瘢痕治疗中使用哪种保湿剂？外用二苯环丙烯酮、芦荟和植物油治疗后的皮肤和瘢痕的主观和客观评估。
Which Moisturizer to Use in Scar Therapy after Burn Injuries? A Subjective and Objective Skin and Scar Evaluation after Topical Treatment with Dexpanthenol, Aloe Vera, and Plant Oil.
机构信息
Clinic for Plastic and Hand Surgery, Burn Care Center, University of Witten/Herdecke, Cologne Merheim Medical Center (CMMC), 51109 Cologne, Germany.
Institute for Research in Operative Medicine (IFOM), Faculty of Health, Witten/Herdecke University, 51109 Cologne, Germany.
出版信息
Medicina (Kaunas). 2023 Oct 21;59(10):1874. doi: 10.3390/medicina59101874.
Good scar management in burn care is essential. Nevertheless, there are no consistent recommendations regarding moisturizers for scar management. Our aim was to investigate and compare the effects of commonly used products on normal skin and burn scars. A total of 30 skin-healthy (control group) and 12 patients with burn scars were included in this study. For an intraindividual comparison, each participant received creams consisting of dexpanthenol (P), aloe vera (A), and a natural plant oil (O) with instructions to apply them daily to a previously defined area for at least 28 days. Objective scar evaluation was performed with Visioscan; Tewameter; Cutometer, and the Oxygen To See device. Subjective evaluation was performed with an "application" questionnaire, the Patient and Observer Scar Assessment Scale (POSAS), and with the "best of three" questionnaire. After (A) a high trend of amelioration of +30%, TEWL was detected on the scar area. Blood flow increased slightly on healthy skin areas after (A) application to +104%. The application of (A) on healthy skin demonstrated a positive effect on the parameters of scaliness (+22%, < 0.001), softness (+14%, = 0.046), roughness R1 (+16%, < 0.001) and R2 (+17%, = 0.000), volume (+22%, < 0.001), and surface area (+7%, < 0.001) within the control group. After (P), a significant improvement of the baseline firmness parameter of +14.7% was detected ( = 0.007). (P) also showed a beneficial effect on the parameters of R1 (+7%, = 0.003), R2 (+6%, = 0.001), and volume (+17%, = 0.001). (O) lead to a statistically significant improvement of volume (+15%, = 0.009). Overall, most study participants stated (A) to be the "best of three". (A) performed statistically best, and is a well-tolerated moisturizing product. However, further quantitative studies are needed to provide statistically significant clarification for uniform recommendations for scar therapy.
烧伤后良好的疤痕管理至关重要。然而，目前对于疤痕管理用保湿剂尚没有一致的推荐意见。我们的目的是调查和比较常用产品对正常皮肤和烧伤疤痕的影响。本研究共纳入 30 例皮肤健康者（对照组）和 12 例烧伤疤痕患者。为了进行个体内比较，每位参与者接受含有二苯羟乙酸硅宁（Dexpanthenol，D）、库拉索芦荟（Aloe vera，A）和天然植物油（O）的乳膏，每天涂抹于先前定义的区域，至少 28 天。采用 Visioscan、Tewameter、Cutometer 和 Oxygen To See 设备进行客观的疤痕评估。采用“应用”问卷、患者和观察者疤痕评估量表（POSAS）和“最佳三选一”问卷进行主观评估。应用 A 后，疤痕区域的 TEWL 检测到高趋势改善率为+30%。应用 A 后，健康皮肤区域的血流量略有增加，增加率为+104%。A 在健康皮肤上的应用对鳞屑（+22%，<0.001）、柔软度（+14%，=0.046）、粗糙度 R1（+16%，<0.001）和 R2（+17%，=0.000）、体积（+22%，<0.001）和表面积（+7%，<0.001）等参数有积极影响。应用 P 后，检测到基线硬度参数的显著改善，改善率为+14.7%（=0.007）。P 还对 R1（+7%，=0.003）、R2（+6%，=0.001）和体积（+17%，=0.001）参数有有益影响。O 导致体积的统计学显著改善（+15%，=0.009）。总的来说，大多数研究参与者认为 A 是“最佳三选一”。A 在统计学上表现最好，是一种耐受良好的保湿产品。然而，需要进一步的定量研究为疤痕治疗的统一推荐提供统计学上的明确证据。
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