Sorovou Glykeria, Schinas Georgios, Pasxali Aggeliki, Tzoukmani Angeliki, Tryfinopoulou Kyriaki, Gogos Charalambos, Dimopoulos George, Akinosoglou Karolina
Microbiology Laboratory, General Hospital of Corfu, 49100 Corfu, Greece.
School of Medicine, University of Patras, 26504 Patras, Greece.
Microorganisms. 2023 Oct 11;11(10):2537. doi: 10.3390/microorganisms11102537.
Antimicrobial resistance is a significant global health challenge, with pneumoniae being one of the most common antibiotic-resistant pathogens. This study provides an in-depth analysis of the prevalence and resistance patterns of antibiotic-resistant in the General Hospital of Corfu, Greece, between 2019 and 2022, with the aim of understanding the potential impact of the COVID-19 pandemic on the epidemiology of this bacterium. Utilizing a retrospective epidemiological approach, this study analyzed 212 isolates obtained from the hospital's Microbiology Department. These isolates were subjected to genotypic and phenotypic identification, with resistance genes (bla-KPC, bla-NDM, bla-VIM, bla-OXA-48, and mcr-1) and antibiotic resistance patterns as the primary focus. The results revealed a significant shift in resistance gene prevalence, with a notable increase in bla-KPC from 16.67% in 2021 to 58.46% in 2022, and a decrease in bla-NDM from 81.48% in 2021 to 38.46% in 2022. In terms of antibiotic resistance patterns, there was a consistent increase in resistance to amikacin and a significant decrease in resistance to ceftazidime/avibactam. These findings underscore the dynamic nature of carbapenem-resistant (CRKP) resistance and highlight the need for ongoing surveillance and adaptive therapeutic strategies in the face of evolving resistance patterns.
抗菌药物耐药性是一项重大的全球健康挑战，肺炎克雷伯菌是最常见的耐药病原体之一。本研究深入分析了2019年至2022年希腊科孚岛总医院耐抗生素肺炎克雷伯菌的流行情况和耐药模式，旨在了解新冠疫情对该细菌流行病学的潜在影响。本研究采用回顾性流行病学方法，分析了从医院微生物科获得的212株分离株。这些分离株进行了基因型和表型鉴定，主要关注耐药基因（bla-KPC、bla-NDM、bla-VIM、bla-OXA-48和mcr-1）和抗生素耐药模式。结果显示耐药基因流行情况发生了显著变化，bla-KPC从2021年的16.67%显著增加到2022年的58.46%，bla-NDM从2021年的81.48%下降到2022年的38.46%。在抗生素耐药模式方面，对阿米卡星的耐药性持续增加，对头孢他啶/阿维巴坦的耐药性显著下降。这些发现强调了耐碳青霉烯类肺炎克雷伯菌（CRKP）耐药性的动态性质，并突出了面对不断演变的耐药模式持续监测和适应性治疗策略的必要性。
