镧系元素有机盐：合成、表征及细胞毒性研究。
Lanthanide-Based Organic Salts: Synthesis, Characterization, and Cytotoxicity Studies.
机构信息
Associated Laboratory for Green Chemistry (LAQV) of the Network of Chemistry and Technology (REQUIMTE), Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Campus da Caparica, 2829-516 Caparica, Portugal.
ITQB NOVA-Instituto de Tecnologia Química e Biológica António Xavier, Avenida da República, Estação Agronómica Nacional, 2780-157 Oeiras, Portugal.
出版信息
Molecules. 2023 Oct 18;28(20):7152. doi: 10.3390/molecules28207152.
The formulation of magnetic ionic liquids (MILs) or organic salts based on lanthanides as anions has been explored. In this work, a set of choline-family-based salts, and two other, different cation families, were combined with Gadolinium(III) and Terbium(III) anions. Synthetic methodologies were previously optimized, and all organic salts were obtained as solids with melting temperatures higher than 100 °C. The magnetic moments obtained for the Gd(III) salts were, as expected, smaller than those obtained for the Tb(III)-based compounds. The values for Gd(III) and Tb(III) magnetic salts are in the range of 6.55-7.30 MB and 8.22-9.34 MB, respectively. It is important to note a correlation between the magnetic moments obtained for lanthanides, and the structural features of the cation. The cytotoxicity of lanthanide-based salts was also evaluated using 3T3, 293T, Caco2, and HepG2 cells, and it was revealed that most of the prepared compounds are not toxic.
已经探索了基于镧系元素作为阴离子的磁性离子液体（MILs）或有机盐的配方。在这项工作中，将一组基于胆碱的盐与两种不同的阳离子家族与钆（III）和铽（III）阴离子结合。先前已经优化了合成方法，所有有机盐都以熔点高于 100°C 的固体形式获得。对于 Gd（III）盐获得的磁矩，如预期的那样，小于基于 Tb（III）的化合物获得的磁矩。Gd（III）和 Tb（III）磁性盐的磁矩值分别在 6.55-7.30 MB 和 8.22-9.34 MB 范围内。值得注意的是，镧系元素获得的磁矩与阳离子的结构特征之间存在相关性。还使用 3T3、293T、Caco2 和 HepG2 细胞评估了基于镧系元素的盐的细胞毒性，结果表明大多数制备的化合物没有毒性。
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