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有关有机酸用于化学焕肤治疗寻常痤疮的疗效的全面文献综述。

A Comprehensive Bibliographic Review Concerning the Efficacy of Organic Acids for Chemical Peels Treating Acne Vulgaris.

机构信息

Department of Pharmaceutical and Therapeutic Chemistry, Faculty of Pharmacy, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Tîrgu Mureș, 540142 Târgu Mureș, Romania.

出版信息

Molecules. 2023 Oct 22;28(20):7219. doi: 10.3390/molecules28207219.

Abstract

Acne vulgaris stands out as the most prevalent skin disorder among teenagers and young adults, causing physical discomfort and considerable economic and psychological burdens on individuals and society. A wide range of topical and systemic therapies are available in acne treatment. Chemical peeling is a skin resurfacing technique designed to rebuild healthy skin using exfoliating substances, a simple and affordable process with various dermatological uses. Chemical peels, classified as superficial, medium, and deep, have been utilized for acne vulgaris and multiple other skin issues. In these chemical peels, a diverse range of chemical substances is employed, each with its unique mode of action. Among these, α-hydroxy and β-hydroxy acids have gathered attention for their efficacy in reducing acne lesions and enhancing overall skin appearance. Acids, such as salicylic acid, glycolic acid, or lactic acid, are commonly used in chemical peels due to their exfoliating and sebum-regulating properties. Despite the widespread use of these acids, there exists a lack of consensus regarding the most effective acid type and concentration for treating acne-prone skin. This review aims to bridge this knowledge gap by evaluating the effectiveness and safety of various organic acids used in chemical peels specifically for acne-prone skin. The findings of this comprehensive bibliographic review indicate that organic acid-based chemical peels represent effective and safe treatment options for individuals with acne-prone skin. Their adaptability sets these treatments apart; the choice of organic acid can be tailored to meet individual patient needs and tolerability levels. This personalized approach ensures that patients receive optimal care while minimizing the risks associated with the treatment. As research in this field progresses, it is anticipated that a more nuanced understanding of the ideal acid type and concentration will emerge, further enhancing the efficacy and safety of chemical peels for acne-prone skin.

摘要

寻常痤疮是青少年和年轻人中最常见的皮肤疾病,给个人和社会带来身体不适和相当大的经济和心理负担。痤疮的治疗有多种局部和系统疗法。化学焕肤是一种使用剥落物质重塑健康皮肤的皮肤表面重建技术,是一种简单且经济实惠的过程,具有多种皮肤科用途。化学焕肤根据深度分为浅层、中层和深层,已用于治疗寻常痤疮和多种其他皮肤问题。在这些化学焕肤中,使用了多种不同的化学物质,每种物质都有其独特的作用模式。其中,α-羟基酸和β-羟基酸因其减少痤疮皮损和改善整体皮肤外观的功效而受到关注。由于具有去角质和调节皮脂的特性,水杨酸、甘醇酸或乳酸等酸类物质通常用于化学焕肤中。尽管这些酸类物质被广泛使用,但对于治疗痤疮皮肤最有效的酸类类型和浓度仍缺乏共识。本综述旨在通过评估专门用于治疗痤疮皮肤的各种有机果酸在化学焕肤中的有效性和安全性来弥补这一知识空白。这项全面的文献综述研究结果表明,基于有机果酸的化学焕肤是治疗痤疮皮肤的有效且安全的选择。其适应性使这些治疗方法脱颖而出;可以根据个体患者的需求和耐受性来选择有机酸。这种个性化方法确保患者获得最佳护理,同时最大限度地降低治疗相关风险。随着该领域研究的进展,可以预期会对理想的酸类类型和浓度有更细致的了解,从而进一步提高针对痤疮皮肤的化学焕肤的疗效和安全性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3c8/10608815/a386b632ee8c/molecules-28-07219-g001.jpg

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