Dayal Surabhi, Amrani Ashish, Sahu Priyadarshini, Jain Vijay Kumar
Department of Dermatology, Venereology and Leprology, Pt B D Sharma University of Health Sciences, Rohtak, Haryana, India.
J Cosmet Dermatol. 2017 Mar;16(1):43-51. doi: 10.1111/jocd.12266. Epub 2016 Aug 25.
Chemical peeling is a well-identified therapeutic modality for acne vulgaris (AV). Jessner's solution (JS) is a known peeling agent for acne since more than 100 years. Salicylic acid (SA) peel is a well-established peeling agent for acne. There is paucity of literature comparing the current peeling agents of choice, that is, SA with the older peeling agents, that is, JS for acne.
To compare the efficacy and safety of 30% SA vs. JS peels in treatment of mild-to-moderate facial acne in Indian patients.
A total of 40 patients with mild-to-moderate AV were enrolled for 12 weeks and were randomly divided into two groups: group 1, 30% SA peels and group 2, JS peels were performed 2 weeks apart with total of six peels in 12-week duration. Clinical improvement was assessed objectively using Michaelsson acne scores (MAS) and clinical photographs. Side effects were observed at each visit.
At the end of therapy, improvement in MAS and percentage decrease in MAS were significantly higher in group 1 as compared to group 2. Likewise, decrease in mean comedone counts in group 1 was significantly higher as compared to group 2. However, there was no statistically significant difference in the decrease in mean papule and pustule counts between the two groups. Both the groups tolerated the peels well.
Thus, 30% SA peels were more effective than JS peels in treatment of noninflammatory lesions, that is, comedones and in overall improvement of mild-to-moderate facial acne vulgaris.
化学剥脱术是治疗寻常痤疮（AV）的一种公认的治疗方式。杰斯纳溶液（JS）作为一种剥脱剂用于治疗痤疮已有100多年的历史。水杨酸（SA）剥脱术是一种成熟的痤疮剥脱剂。目前缺乏将现有的首选剥脱剂，即SA，与较老的剥脱剂，即用于治疗痤疮的JS进行比较的文献。
比较30%SA剥脱术与JS剥脱术治疗印度患者轻至中度面部痤疮的疗效和安全性。
共纳入40例轻至中度AV患者，为期12周，随机分为两组：第1组，采用30%SA剥脱术；第2组，采用JS剥脱术，两组剥脱术间隔2周进行，在12周内共进行6次剥脱。使用迈克尔森痤疮评分（MAS）和临床照片客观评估临床改善情况。每次就诊时观察副作用。
治疗结束时，第1组的MAS改善情况和MAS降低百分比均显著高于第2组。同样，第1组平均粉刺计数的减少也显著高于第2组。然而，两组之间平均丘疹和脓疱计数的减少没有统计学上的显著差异。两组对剥脱术的耐受性都很好。
因此，30%SA剥脱术在治疗非炎性皮损，即粉刺方面比JS剥脱术更有效，并且在整体改善轻至中度寻常面部痤疮方面效果更佳。
